TRAP1 and EXT1

Number of citations of the paper that reports this interaction (PubMedID 10545594)
0

Data Source:
HPRD (two hybrid, in vitro)

		TRAP1	EXT1
Description		TNF receptor associated protein 1	exostosin glycosyltransferase 1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Intracellular Organelle Lumen	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Organelle Membrane Synapse Catalytic Complex
	Molecular Function	Nucleotide Binding RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Protein Folding Translational Attenuation Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Polysaccharide Biosynthetic Process Cell Morphogenesis Ossification Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Hematopoietic Progenitor Cell Differentiation Hypersensitivity Heart Field Specification Chondrocyte Hypertrophy Endochondral Bone Growth Glycosaminoglycan Biosynthetic Process Protein Glycosylation Vacuole Organization Cell Adhesion Cell Surface Receptor Signaling Pathway Smoothened Signaling Pathway Gastrulation Axon Guidance Brain Development Endoderm Development Mesoderm Development Regulation Of Blood Pressure Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus Response To Light Intensity Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neural Crest Cell Differentiation Heparan Sulfate Proteoglycan Biosynthetic Process Stem Cell Division Antigen Processing And Presentation Optic Nerve Development Olfactory Bulb Development Hair Cycle Process Protein Catabolic Process Proteoglycan Biosynthetic Process Collagen Fibril Organization Heparin Proteoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process BMP Signaling Pathway Hair Follicle Morphogenesis Neuron Projection Development Glomerular Basement Membrane Development Cell Adhesion Mediated By Integrin Social Behavior Synaptic Transmission, Glutamatergic Multicellular Organism Growth Chondrocyte Proliferation Limb Joint Morphogenesis Dendritic Cell Migration Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Fluid Transport Wound Healing Vasodilation Fear Response Ossification Involved In Bone Maturation Cellular Response To Fibroblast Growth Factor Stimulus Cell Fate Commitment Bone Resorption Embryonic Morphogenesis Sebaceous Gland Development Chondroitin Sulfate Proteoglycan Metabolic Process Multicellular Organismal-level Water Homeostasis Leukocyte Tethering Or Rolling Sulfation Sodium Ion Homeostasis Heart Contraction Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Morphogenesis Endochondral Bone Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Mesenchyme Development Smoothened Signaling Pathway Involved In Lung Development Developmental Growth Involved In Morphogenesis Sweat Gland Development Hematopoietic Stem Cell Homeostasis Motor Behavior Perichondral Bone Morphogenesis Stomach Development Protein-containing Complex Assembly Dendrite Self-avoidance Response To Growth Factor Response To Heparin Vocalization Behavior Basement Membrane Organization Cellular Response To BMP Stimulus Podocyte Differentiation Embryonic Skeletal Joint Development Lymphocyte Migration Into Lymphoid Organs Hematopoietic Stem Cell Migration To Bone Marrow Cellular Response To Virus Bone Growth Tight Junction Organization Mesenchymal Cell Differentiation Involved In Bone Development Cranial Skeletal System Development Response To Leukemia Inhibitory Factor
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases			Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 27863252 32888494)	Adult body size ( 32376654) Autism spectrum disorder ( 28540026) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Depression in smokers ( 30219690) Endometrial cancer (Non-endometrioid histology) ( 30093612) Facial attractiveness (female raters) ( 30946739) General cognitive ability ( 29844566) Height ( 19893584) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Urate levels in obese individuals ( 25811787) White blood cell count (basophil) ( 29403010)
Interacting Genes		17 interacting genes: APP ESX1 EXT1 EXT2 FXR1 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	6 interacting genes: EXT2 FBXW7 GOLPH3 GOLPH3L NOTCH1 TRAP1
Entrez ID		10131	2131
HPRD ID		05868	00598
Ensembl ID		ENSG00000126602	ENSG00000182197
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	Q16394
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05 7C7B 7C7C 7KCK 7KCL 7KCM 7KLU 7KLV 7U8U 7U8V 7U8W 7U8X 7ULK	7SCH 7SCJ 7SCK 7UQX 7UQY 7ZAY
Enriched GO Terms of Interacting Partners?		Membrane Raft Receptor Complex Regulation Of Inflammatory Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Defense Response Negative Regulation Of Multicellular Organismal Process N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Regulation Of Extracellular Matrix Organization Cell Activation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity Positive Regulation Of Extracellular Matrix Organization Transforming Growth Factor Beta Ligand-receptor Complex Microglial Cell Activation Activin Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Mesenchymal Cell Differentiation Leukocyte Activation Involved In Inflammatory Response Regulation Of Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Myeloid Leukocyte Activation Ventricular Septum Morphogenesis Chondrocyte Hypertrophy Animal Organ Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Gene Expression Endochondral Bone Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Multicellular Organismal Process Gastrulation SMAD Binding Protein Heterodimerization Activity Heparin Proteoglycan Biosynthetic Process Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Sebaceous Gland Development Transforming Growth Factor Beta Receptor Activity Lipopeptide Binding Developmental Process Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Golgi Membrane Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Gene Expression Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization To Organelle Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Mitochondrial Intermembrane Space N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity UDP-N-acetylglucosamine Transferase Complex Heparan Sulfate N-acetylglucosaminyltransferase Activity MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Notch Signaling Pathway Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Negative Regulation Of Epithelial Cell Proliferation Auditory Receptor Cell Fate Commitment Notch Signaling Involved In Heart Development Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Cardiac Right Ventricle Formation Glomerular Mesangial Cell Development Regulation Of Apoptotic Process Cell Migration Involved In Endocardial Cushion Formation Chemical Synaptic Transmission, Postsynaptic Compartment Pattern Specification Mitral Valve Formation
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