TRAP1 and TLR6

Number of citations of the paper that reports this interaction (PMID 16482509)
13

Data Source:
HPRD (two hybrid)

		TRAP1	TLR6
Gene Name		TNF receptor-associated protein 1	toll-like receptor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Lipid Particle Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Phagocytic Vesicle Membrane Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Poly(A) RNA Binding Unfolded Protein Binding	Receptor Activity Transmembrane Signaling Receptor Activity Diacyl Lipopeptide Binding Protein Heterodimerization Activity Lipopeptide Binding
	Biological Process	Response To Stress Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 6 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Diacyl Bacterial Lipopeptide
Pathways			Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS		Metabolite levels (HVA/5-HIAA ratio) ( 23319000)	Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		14 interactors: APP ESX1 EXT1 EXT2 HGS PSMC4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	3 interactors: BTK TLR2 TRAP1
Entrez ID		10131	10333
HPRD ID		05868	05656
Ensembl ID		ENSG00000126602	ENSG00000174130
Uniprot IDs		B4DR68 F5H897 Q12931 Q53FS6	B2R933 Q9Y2C9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization Signal Transduction Embryonic Morphogenesis Regulation Of Protein Phosphorylation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Embryo Development Signaling Positive Regulation Of Metabolic Process Cell Communication Positive Regulation Of Cellular Metabolic Process Detection Of Bacterial Lipoprotein Chordate Embryonic Development Regulation Of Protein Localization Embryo Development Ending In Birth Or Egg Hatching Gastrulation Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process In Utero Embryonic Development Endothelial Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Interleukin-6 Biosynthetic Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of SMAD Protein Import Into Nucleus Cell Death Death Detection Of Molecule Of Bacterial Origin Cellular Response To Bacterial Lipopeptide Regulation Of Protein Transport Anatomical Structure Morphogenesis Positive Regulation Of Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Interleukin-6 Production Pathway-restricted SMAD Protein Phosphorylation Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Proliferation Palate Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Activation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport	Response To Molecule Of Fungal Origin Response To Fungus I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Reactive Oxygen Species Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Chloramphenicol Transport Regulation Of B Cell Cytokine Production Induction By Symbiont Of Defense-related Host Nitric Oxide Production Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Fungal Origin Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Response To Defense-related Host Nitric Oxide Production Positive Regulation Of Interleukin-18 Production Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Cellular Respiration Immune Response-activating Cell Surface Receptor Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Antibiotic Transport Central Nervous System Myelin Formation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Peptidoglycan Response To Host Immune Response Inflammatory Response Detection Of Bacterial Lipoprotein Immune Response-regulating Signaling Pathway Leukocyte Activation Negative Regulation Of Interleukin-17 Production Cellular Response To Bacterial Lipopeptide Regulation Of Cytokine Production Positive Regulation Of Toll-like Receptor Signaling Pathway Histamine Secretion By Mast Cell Response To Peptidoglycan Regulation Of Cellular Respiration Microglial Cell Activation
Tagcloud ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tollip tuberculin uganda
Tagcloud (Difference) ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tollip tuberculin uganda
Tagcloud (Intersection) ?