TRAP1 and TLR6

Number of citations of the paper that reports this interaction (PubMedID 16482509)
45

Data Source:
HPRD (two hybrid)

		TRAP1	TLR6
Description		TNF receptor associated protein 1	toll like receptor 6
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Intracellular Organelle Lumen	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Nucleotide Binding RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Diacyl Lipopeptide Binding Identical Protein Binding Protein Heterodimerization Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Protein Folding Translational Attenuation Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Response To Bacterial Lipoprotein Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of Inflammatory Response Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand RSV-host interactions
Drugs			Pam2csk4
Diseases
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 27863252 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569)
Interacting Genes		17 interacting genes: APP ESX1 EXT1 EXT2 FXR1 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	4 interacting genes: BTK HRAS TLR2 TRAP1
Entrez ID		10131	10333
HPRD ID		05868	05656
Ensembl ID		ENSG00000126602	ENSG00000174130
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	B2R933 Q9Y2C9
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05 7C7B 7C7C 7KCK 7KCL 7KCM 7KLU 7KLV 7U8U 7U8V 7U8W 7U8X 7ULK	4OM7
Enriched GO Terms of Interacting Partners?		Membrane Raft Receptor Complex Regulation Of Inflammatory Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Defense Response Negative Regulation Of Multicellular Organismal Process N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Regulation Of Extracellular Matrix Organization Cell Activation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity Positive Regulation Of Extracellular Matrix Organization Transforming Growth Factor Beta Ligand-receptor Complex Microglial Cell Activation Activin Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Mesenchymal Cell Differentiation Leukocyte Activation Involved In Inflammatory Response Regulation Of Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Myeloid Leukocyte Activation Ventricular Septum Morphogenesis Chondrocyte Hypertrophy Animal Organ Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Gene Expression Endochondral Bone Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Multicellular Organismal Process Gastrulation SMAD Binding Protein Heterodimerization Activity Heparin Proteoglycan Biosynthetic Process Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Sebaceous Gland Development Transforming Growth Factor Beta Receptor Activity Lipopeptide Binding Developmental Process Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition	Positive Regulation Of Type I Hypersensitivity Regulation Of Phagocytosis Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Activation Of Immune Response Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Affinity Maturation Immune Response-activating Signaling Pathway Glial Cell Development GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Triacyl Lipopeptide Binding Detection Of Diacyl Bacterial Lipopeptide Translational Attenuation Defense Response To Other Organism Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Intracellular Signal Transduction Phospholipase C Activator Activity Cellular Response To Triacyl Bacterial Lipopeptide Microglia Development Positive Regulation Of Matrix Metallopeptidase Secretion Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Inflammatory Response Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Cellular Response To Molecule Of Fungal Origin Regulation Of Cytokine Production Detection Of Bacterial Lipoprotein
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