TRAP1 and ESX1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TRAP1	ESX1
Gene Name		TNF receptor-associated protein 1	ESX homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Lipid Particle Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Poly(A) RNA Binding Unfolded Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding
	Biological Process	Response To Stress Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Labyrinthine Layer Morphogenesis Labyrinthine Layer Blood Vessel Development
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA/5-HIAA ratio) ( 23319000)
Protein-Protein Interactions		14 interactors: APP ESX1 EXT1 EXT2 HGS PSMC4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	2 interactors: EXOC2 TRAP1
Entrez ID		10131	80712
HPRD ID		05868	06503
Ensembl ID		ENSG00000126602	ENSG00000123576
Uniprot IDs		B4DR68 F5H897 Q12931 Q53FS6	Q8N693
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization Signal Transduction Embryonic Morphogenesis Regulation Of Protein Phosphorylation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Embryo Development Signaling Positive Regulation Of Metabolic Process Cell Communication Positive Regulation Of Cellular Metabolic Process Detection Of Bacterial Lipoprotein Chordate Embryonic Development Regulation Of Protein Localization Embryo Development Ending In Birth Or Egg Hatching Gastrulation Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process In Utero Embryonic Development Endothelial Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Interleukin-6 Biosynthetic Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of SMAD Protein Import Into Nucleus Cell Death Death Detection Of Molecule Of Bacterial Origin Cellular Response To Bacterial Lipopeptide Regulation Of Protein Transport Anatomical Structure Morphogenesis Positive Regulation Of Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Interleukin-6 Production Pathway-restricted SMAD Protein Phosphorylation Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Proliferation Palate Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Activation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport	Negative Regulation Of Cellular Respiration Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Golgi To Plasma Membrane Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Response To Oxidative Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Post-Golgi Vesicle-mediated Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic	apparatus assembled assembly colocalize conservation deletions determinant establishment exploit fluorescently fluoro governing illustrates lapse localization localize msesx1 mtbesx mtbesx1 mycobacterium pathogenicity polar pole remarkably septal smegmatis tagged virulence
Tagcloud (Difference) ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic	apparatus assembled assembly colocalize conservation deletions determinant establishment exploit fluorescently fluoro governing illustrates lapse localization localize msesx1 mtbesx mtbesx1 mycobacterium pathogenicity polar pole remarkably septal smegmatis tagged virulence
Tagcloud (Intersection) ?