RAD50 and RECQL5

Number of citations of the paper that reports this interaction (PMID 19270065)
16

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RAD50	RECQL5
Gene Name		RAD50 homolog (S. cerevisiae)	RecQ protein-like 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleoplasm Membrane Mre11 Complex Site Of Double-strand Break Pronucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm DNA-directed RNA Polymerase II, Holoenzyme Nuclear Membrane
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Protein Binding, Bridging Metal Ion Binding	RNA Polymerase II Core Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding ATP-dependent Helicase Activity
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Mitotic Nuclear Division DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cell Division Chromosome Separation
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination MRN complex relocalizes to nuclear foci Homologous Recombination Repair Cellular Senescence Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Asthma ( 20159242) IgE levels ( 18846228)
Protein-Protein Interactions		8 interactors: DCLRE1C EP300 MDC1 MRE11A NBN RECQL5 RINT1 TERF2IP	19 interactors: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11A MTSS1 NBN PLK1 POLR2A RAD50 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		10111	9400
HPRD ID		04950	04806
Ensembl ID		ENSG00000113522	ENSG00000108469
Uniprot IDs		A5D6Y3 Q92878	B3KQK2 O94762 Q6P4G0 Q8WYH5
PDB IDs			4BK0
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Metabolic Process DNA Repair Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Mitotic DNA Damage Checkpoint Intra-S DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Telomere Maintenance Via Telomerase Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Process Response To Stress Positive Regulation Of Protein Autophosphorylation Mitotic G2 DNA Damage Checkpoint DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint RNA-dependent DNA Replication Regulation Of Protein Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Checkpoint G2 DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Replication DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Recombination Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Histone H2B Acetylation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cell Cycle DNA Catabolic Process, Endonucleolytic Negative Regulation Of DNA Metabolic Process Regulation Of Type I Interferon Production	DNA Conformation Change Positive Regulation Of Protein Autophosphorylation Meiotic Cell Cycle Regulation Of Protein Autophosphorylation G2 DNA Damage Checkpoint Chromosome Organization Cellular Response To Stress Meiotic Nuclear Division Regulation Of Mitotic Recombination Telomere Maintenance Telomere Maintenance Via Telomerase DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Mitotic G2 DNA Damage Checkpoint Cell Cycle Process DNA Metabolic Process Mitotic Cell Cycle Process DNA Topological Change RNA-dependent DNA Replication Organelle Organization Double-strand Break Repair Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Kinase Activity Mitotic Cell Cycle Checkpoint Telomere Maintenance Via Telomere Lengthening Cellular Response To DNA Damage Stimulus Response To Stress Mitotic Cytokinesis Reciprocal Meiotic Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation Cell Cycle Checkpoint DNA Recombination Positive Regulation Of Transferase Activity Reproduction DNA Repair Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of DNA Recombination Cellular Nitrogen Compound Metabolic Process Activation Of APC-Cdc20 Complex Activity Transcription, RNA-templated Glycine Betaine Biosynthetic Process From Choline Adherens Junction Maintenance Positive Regulation Of Cellular Metabolic Process Cell Proliferation
Tagcloud ?		53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine
Tagcloud (Difference) ?		53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine
Tagcloud (Intersection) ?