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RAD50 and NBN
Number of citations of the paper that reports this interaction (PubMedID
11238951
)
30
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
RAD50
NBN
Description
RAD50 double strand break repair protein
nibrin
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Chromosome
Membrane
Mre11 Complex
Site Of Double-strand Break
BRCA1-C Complex
Chromosomal Region
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Golgi Apparatus
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Nuclear Inclusion Body
BRCA1-C Complex
Chromosomal Region
Molecular Function
Single-stranded DNA Endodeoxyribonuclease Activity
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Double-stranded Telomeric DNA Binding
Protein Binding
ATP Binding
3'-5' Exonuclease Activity
Hydrolase Activity
ATP Hydrolysis Activity
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Single-stranded Telomeric DNA Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
G-quadruplex DNA Binding
Damaged DNA Binding
Protein Binding
Histone Binding
Protein Serine/threonine Kinase Activator Activity
Phosphorylation-dependent Protein Binding
DNA-binding Transcription Factor Binding
Chromatin-protein Adaptor Activity
Biological Process
Regulation Of Mitotic Recombination
Telomere Maintenance Via Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Repair
Double-strand Break Repair
DNA Recombination
DNA Damage Response
Telomere Maintenance Via Telomerase
Reciprocal Meiotic Recombination
Telomeric 3' Overhang Formation
Positive Regulation Of Telomere Maintenance
Homologous Recombination
Mitotic G2/M Transition Checkpoint
Chromosome Organization
Meiotic Cell Cycle
R-loop Processing
Chromosome Organization Involved In Meiotic Cell Cycle
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
In Utero Embryonic Development
Blastocyst Growth
DNA Repair
Double-strand Break Repair
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Neuroblast Proliferation
Regulation Of DNA-templated DNA Replication Initiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protection From Non-homologous End Joining At Telomere
Telomeric 3' Overhang Formation
Positive Regulation Of Telomere Maintenance
Homologous Recombination
Telomere Maintenance In Response To DNA Damage
Mitotic G2/M Transition Checkpoint
Isotype Switching
Neuromuscular Process Controlling Balance
Meiotic Cell Cycle
Regulation Of Cell Cycle
R-loop Processing
Protein K63-linked Ubiquitination
T-circle Formation
Telomere Maintenance Via Telomere Trimming
Intrinsic Apoptotic Signaling Pathway
Double-strand Break Repair Via Alternative Nonhomologous End Joining
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Positive Regulation Of Double-strand Break Repair
Pathways
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Asthma (
20159242
31959851
31619474
30929738
29273806
27611488
27182965
)
Asthma (childhood onset) (
30929738
24241537
29273806
)
Asthma (moderate or severe) (
30552067
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
23886662
25574825
25865352
)
Eosinophil count (
29403010
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Eosinophilic esophagitis (
34506852
)
IgE levels (
18846228
)
Inflammatory skin disease (
25574825
)
Itch intensity from mosquito bite (
28199695
)
Neutrophil percentage of white cells (
32888494
27863252
)
Polycystic ovary syndrome (
26416764
30566500
)
Rosacea symptom severity (
29771307
)
Sum eosinophil basophil counts (
27863252
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Interacting Genes
15 interacting genes:
ATM
CEBPA
CREBBP
DCLRE1C
EP300
MDC1
MRE11
NABP2
NBN
RECQL5
RINT1
SUMO2
TERF2IP
TP53BP1
USP7
35 interacting genes:
ATF2
ATM
ATR
BAP1
BRCA1
CASC3
CCNE1
CDK9
CHEK2
DCLRE1C
EP300
FANCD2
H2AX
H3-4
HIF1A
MDC1
MRE11
NABP2
NAT2
NCL
PRKDC
RAD50
RAD51
RECQL5
SIRT1
SNAI1
SUMO2
TERF1
TLK1
TREX1
UBE2D1
UBE2N
VRK1
XRCC4
XRCC5
Entrez ID
10111
4683
HPRD ID
04950
04050
Ensembl ID
ENSG00000113522
ENSG00000104320
Uniprot IDs
A5D6Y3
Q92878
A0A0C4DG07
O60934
PDB IDs
5GOX
5WQD
7SID
8BAH
Enriched GO Terms of Interacting Partners
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DNA Damage Response
Cellular Response To Stress
Regulation Of DNA Recombination
Regulation Of Double-strand Break Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of DNA Metabolic Process
DNA Metabolic Process
DNA Repair
Double-strand Break Repair
Regulation Of DNA Repair
Positive Regulation Of DNA Metabolic Process
Nucleic Acid Metabolic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of Cell Cycle
Site Of Double-strand Break
DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of Telomere Maintenance
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Telomere Capping
DNA Strand Resection Involved In Replication Fork Processing
Intracellular Signal Transduction
DNA Recombination
Response To Stress
Mitotic G2/M Transition Checkpoint
Chromosome
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Double-strand Break Repair Via Nonhomologous End Joining
Nucleobase-containing Compound Metabolic Process
Recombinational Repair
Negative Regulation Of Cell Cycle Process
Signal Transduction In Response To DNA Damage
Damaged DNA Binding
Mitotic DNA Damage Checkpoint Signaling
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Telomere Maintenance
Positive Regulation Of DNA Recombination
Chromosome, Telomeric Region
Protein Localization To Site Of Double-strand Break
Replication Fork
Nucleoplasm
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Double-strand Break Repair
Telomere Maintenance
Mitotic G2 DNA Damage Checkpoint Signaling
Positive Regulation Of Chromosome Organization
Regulation Of G2/M Transition Of Mitotic Cell Cycle
DNA Damage Response
DNA Metabolic Process
DNA Repair
Double-strand Break Repair
Response To Ionizing Radiation
Nucleoplasm
Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
DNA Recombination
Chromosome, Telomeric Region
DNA Damage Checkpoint Signaling
Response To Radiation
Negative Regulation Of Cell Cycle
Nucleic Acid Metabolic Process
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Regulation Of Cellular Response To Stress
Regulation Of Cell Cycle Phase Transition
Recombinational Repair
Regulation Of Double-strand Break Repair
Telomere Maintenance
Negative Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of Cell Cycle Process
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Cell Cycle
Mitotic DNA Integrity Checkpoint Signaling
Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Telomere Organization
Chromosome
Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Double-strand Break Repair Via Homologous Recombination
Response To Gamma Radiation
Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Site Of Double-strand Break
Cellular Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Response To Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome Organization Involved In Meiotic Cell Cycle
Chromatin Remodeling
Cellular Response To Gamma Radiation
Positive Regulation Of Double-strand Break Repair
DNA Binding
Regulation Of Primary Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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