RAD50 and RINT1

Number of citations of the paper that reports this interaction (PMID 11096100)
17

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAD50	RINT1
Gene Name		RAD50 homolog (S. cerevisiae)	RAD50 interactor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleoplasm Membrane Mre11 Complex Site Of Double-strand Break Pronucleus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Protein Binding, Bridging Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Nucleic Acid Phosphodiester Bond Hydrolysis	Cell Cycle Protein Transport Golgi Vesicle Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination MRN complex relocalizes to nuclear foci Homologous Recombination Repair Cellular Senescence Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Asthma ( 20159242) IgE levels ( 18846228)
Protein-Protein Interactions		8 interactors: DCLRE1C EP300 MDC1 MRE11A NBN RECQL5 RINT1 TERF2IP	43 interactors: ARNT2 BNIP3L C1orf109 CCDC101 CCDC121 CCDC146 CEP57L1 CSPP1 CWF19L2 DCX EPC1 FAM107A FAM110A FAM124B FAM161A FAM81B FAM90A1 GFI1B HDAC4 LMO2 LSP1P3 PIK3R2 RAD50 RB1 RBL1 RBL2 RBM41 RIBC1 RSRC2 RTP5 SCNM1 SFR1 SH2D4A SMARCE1 SNW1 SPTBN1 STRN TXLNA VPS37C XPNPEP1 ZNF655 ZNF697 ZW10
Entrez ID		10111	60561
HPRD ID		04950	15250
Ensembl ID		ENSG00000113522	ENSG00000135249
Uniprot IDs		A5D6Y3 Q92878	Q6NUQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Metabolic Process DNA Repair Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Mitotic DNA Damage Checkpoint Intra-S DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Telomere Maintenance Via Telomerase Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Process Response To Stress Positive Regulation Of Protein Autophosphorylation Mitotic G2 DNA Damage Checkpoint DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint RNA-dependent DNA Replication Regulation Of Protein Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Checkpoint G2 DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Replication DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Recombination Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Histone H2B Acetylation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cell Cycle DNA Catabolic Process, Endonucleolytic Negative Regulation Of DNA Metabolic Process Regulation Of Type I Interferon Production	Chromosome Organization Chromatin Modification Regulation Of Lipid Kinase Activity Chromatin Organization Protein Localization To Chromosome Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Organelle Organization RNA Metabolic Process Protein Localization To Chromosome, Centromeric Region Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of Histone H3-K4 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Mitotic Metaphase Plate Congression Viral Process Positive Regulation Of Cellular Biosynthetic Process Metaphase Plate Congression Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Establishment Of Chromosome Localization Microtubule Anchoring Chromatin Remodeling Regulation Of Histone Methylation Regulation Of Chromosome Organization Mitotic Cell Cycle Positive Regulation Of Vitamin D Receptor Signaling Pathway
Tagcloud ?		53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine	apparatus autophagy checkpoint comprises counterpart cytokinesis decay discuss dsl1 dsl3 endoplasmic endosome golgi intercorrelation metazoan moonlighting nag nrz participate reticulum retrograde sec39 summarize tethering tip20 trafficking transport vesicle zw10
Tagcloud (Difference) ?		53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine	apparatus autophagy checkpoint comprises counterpart cytokinesis decay discuss dsl1 dsl3 endoplasmic endosome golgi intercorrelation metazoan moonlighting nag nrz participate reticulum retrograde sec39 summarize tethering tip20 trafficking transport vesicle zw10
Tagcloud (Intersection) ?