RAD50 and DCLRE1C

Number of citations of the paper that reports this interaction (PMID 15456891)
38

Data Source:
HPRD (in vitro, in vivo)

		RAD50	DCLRE1C
Gene Name		RAD50 homolog (S. cerevisiae)	DNA cross-link repair 1C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleoplasm Membrane Mre11 Complex Site Of Double-strand Break Pronucleus	Nucleus
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Protein Binding, Bridging Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity 5'-3' Exonuclease Activity
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Nucleic Acid Phosphodiester Bond Hydrolysis	Telomere Maintenance DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Response To Ionizing Radiation B Cell Differentiation V(D)J Recombination Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination MRN complex relocalizes to nuclear foci Homologous Recombination Repair Cellular Senescence Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Asthma ( 20159242) IgE levels ( 18846228)
Protein-Protein Interactions		8 interactors: DCLRE1C EP300 MDC1 MRE11A NBN RECQL5 RINT1 TERF2IP	11 interactors: ATM ATR BRCA1 DDB1 DDB2 MRE11A NBN PRKDC PSMD9 RAD50 TP53BP1
Entrez ID		10111	64421
HPRD ID		04950	05817
Ensembl ID		ENSG00000113522	ENSG00000152457
Uniprot IDs		A5D6Y3 Q92878	B3KMX5 Q96SD1
PDB IDs			3W1B 3W1G 4HTP
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Metabolic Process DNA Repair Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Mitotic DNA Damage Checkpoint Intra-S DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Telomere Maintenance Via Telomerase Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Process Response To Stress Positive Regulation Of Protein Autophosphorylation Mitotic G2 DNA Damage Checkpoint DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint RNA-dependent DNA Replication Regulation Of Protein Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Checkpoint G2 DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Replication DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Recombination Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Histone H2B Acetylation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cell Cycle DNA Catabolic Process, Endonucleolytic Negative Regulation Of DNA Metabolic Process Regulation Of Type I Interferon Production	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress DNA Damage Checkpoint DNA Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Stress G2 DNA Damage Checkpoint Cell Cycle Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Mitotic G2 DNA Damage Checkpoint Chromosome Organization Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Protein Autophosphorylation Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation DNA Catabolic Process Cellular Response To Radiation Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Heterocycle Metabolic Process Reciprocal Meiotic Recombination Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Meiotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Tagcloud ?		53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine	alleles breakpoints carrier casp3 catabolism cdh19 centered cnv cnvs cyp2c19 cyp450 dab2ip deletion differed disrupted disturbed encodes estradiol exact finnish inherited itga9 multiplex nested northern participating qpcr singletons unselected
Tagcloud (Difference) ?		53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine	alleles breakpoints carrier casp3 catabolism cdh19 centered cnv cnvs cyp2c19 cyp450 dab2ip deletion differed disrupted disturbed encodes estradiol exact finnish inherited itga9 multiplex nested northern participating qpcr singletons unselected
Tagcloud (Intersection) ?