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RAD50
Gene Name
RAD50 homolog (S. cerevisiae)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome, Telomeric Region
Nucleoplasm
Membrane
Mre11 Complex
Site Of Double-strand Break
Pronucleus
Molecular Function
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
3'-5' Exonuclease Activity
Protein Binding, Bridging
Metal Ion Binding
Biological Process
Regulation Of Mitotic Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Catabolic Process, Endonucleolytic
DNA Repair
Double-strand Break Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Reciprocal Meiotic Recombination
Positive Regulation Of Protein Autophosphorylation
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
DNA Damage/Telomere Stress Induced Senescence
Meiotic recombination
MRN complex relocalizes to nuclear foci
Homologous Recombination Repair
Cellular Senescence
Homologous recombination repair of replication-independent double-strand breaks
Recruitment of repair and signaling proteins to double-strand breaks
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
Double-Strand Break Repair
Drugs
Diseases
GWAS
Asthma (
20159242
)
IgE levels (
18846228
)
Protein-protein Interactions
8 interactors:
DCLRE1C
EP300
MDC1
MRE11A
NBN
RECQL5
RINT1
TERF2IP
Entrez ID
10111
HPRD ID
04950
Ensembl ID
ENSG00000113522
Uniprot IDs
A5D6Y3
Q92878
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cellular Response To DNA Damage Stimulus
DNA Recombination
Telomere Maintenance
Cellular Response To Stress
Double-strand Break Repair
Chromosome Organization
DNA Metabolic Process
DNA Repair
Cell Cycle
Mitotic Cell Cycle Process
Mitotic Cell Cycle
DNA Duplex Unwinding
DNA Geometric Change
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Mitotic DNA Damage Checkpoint
Intra-S DNA Damage Checkpoint
Mitotic DNA Integrity Checkpoint
Telomere Maintenance Via Telomerase
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Response To Stress
Positive Regulation Of Protein Autophosphorylation
Mitotic G2 DNA Damage Checkpoint
DNA Damage Checkpoint
Mitotic Cell Cycle Checkpoint
RNA-dependent DNA Replication
Regulation Of Protein Autophosphorylation
Negative Regulation Of Mitotic Cell Cycle
Telomere Maintenance Via Telomere Lengthening
Cell Cycle Checkpoint
G2 DNA Damage Checkpoint
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Conformation Change
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Organelle Organization
Cellular Nitrogen Compound Metabolic Process
Regulation Of DNA Recombination
Nitrogen Compound Metabolic Process
Positive Regulation Of Type I Interferon Production
Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Histone H2B Acetylation
Negative Regulation Of DNA Recombination At Telomere
Negative Regulation Of Cell Cycle
DNA Catabolic Process, Endonucleolytic
Negative Regulation Of DNA Metabolic Process
Regulation Of Type I Interferon Production
Tagcloud
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53bp1
applies
atr
coimmunoprecipitated
colocalized
combine
damaging
dda
ddas
dividing
dynein
etoposide
explaining
h2ax
interphase
microtubules
mre11
mta
mtas
nbs1
p63
p95
pk
sequestered
sequesters
slowly
synergize
traffic
vincristine