RAD50 and TP53BP1

Number of citations of the paper that reports this interaction (PubMedID 20010693)
81

Data Source:
BioGRID (proximity labelling technology, pull down, affinity chromatography technology, biochemical)

		RAD50	TP53BP1
Description		RAD50 double strand break repair protein	tumor protein p53 binding protein 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Membrane Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Nucleotide Binding DNA Binding DNA Helicase Activity Double-stranded Telomeric DNA Binding Protein Binding ATP Binding 3'-5' Exonuclease Activity Hydrolase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Single-stranded Telomeric DNA Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding G-quadruplex DNA Binding	P53 Binding DNA Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Telomeric DNA Binding Histone Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin-modified Histone Reader Activity Histone H4K20me2 Reader Activity Histone Reader Activity Histone H4K20me Methyltransferase Activity
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Chromosome Organization Involved In Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair	DNA Damage Checkpoint Signaling DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 20159242 31959851 31619474 30929738 29273806 27611488 27182965) Asthma (childhood onset) ( 30929738 24241537 29273806) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 23886662 25574825 25865352) Eosinophil count ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 34506852) IgE levels ( 18846228) Inflammatory skin disease ( 25574825) Itch intensity from mosquito bite ( 28199695) Neutrophil percentage of white cells ( 32888494 27863252) Polycystic ovary syndrome ( 26416764 30566500) Rosacea symptom severity ( 29771307) Sum eosinophil basophil counts ( 27863252) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Antibody level in response to infection ( 25758998) Apolipoprotein A1 levels ( 32203549) Cardiometabolic and hematological traits ( 27668658) Eosinophil count ( 32888494) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Liver volume ( 34128465) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)
Interacting Genes		15 interacting genes: ATM CEBPA CREBBP DCLRE1C EP300 MDC1 MRE11 NABP2 NBN RECQL5 RINT1 SUMO2 TERF2IP TP53BP1 USP7	60 interacting genes: ANKS1A ARAP1 ATM BCL6 BLM BRCA1 BRCA2 C10orf55 CCDC120 CCNB1 CDK1 CEBPA CHEK1 CRB2 CREB5 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AC4 H2AX H4C1 H4C14 H4C16 HGS IFI16 KAT8 KDM1A KLHDC7B LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16 OXER1 PARP1 PAXIP1 PCNT PITX1 POU6F2 PTEN RAD18 RAD50 RAD51 RBL1 RBL2 RELA SPAG9 SPOP SUMO2 TFDP1 TLX3 TP53 UBAP2 USP28 VAC14
Entrez ID		10111	7158
HPRD ID		04950	05569
Ensembl ID		ENSG00000113522	ENSG00000067369
Uniprot IDs		A5D6Y3 Q92878	A6NNK5 Q12888
PDB IDs		5GOX	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT 6VA5 6VIP 7LIN 7LIO 7YQK 8EOM 8F0W 8HKW 8SVG 8SVH 8SVI 8SVJ 8SWJ 8T2D 8U4U 9CKJ
Enriched GO Terms of Interacting Partners?		DNA Damage Response Cellular Response To Stress Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process DNA Metabolic Process DNA Repair Double-strand Break Repair Regulation Of DNA Repair Positive Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Cell Cycle Site Of Double-strand Break DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Phase Transition Regulation Of Telomere Capping DNA Strand Resection Involved In Replication Fork Processing Intracellular Signal Transduction DNA Recombination Response To Stress Mitotic G2/M Transition Checkpoint Chromosome Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Nucleobase-containing Compound Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Recombination Chromosome, Telomeric Region Protein Localization To Site Of Double-strand Break Replication Fork Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Telomere Maintenance Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle	Response To Ionizing Radiation Chromatin Organization Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Response Chromosome, Telomeric Region Regulation Of Cell Cycle Process Nucleoplasm Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Chromatin Remodeling Negative Regulation Of Cell Cycle DNA Repair Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Cellular Response To Radiation DNA Binding Response To Radiation DNA Damage Checkpoint Signaling Regulation Of DNA Recombination Cellular Response To Ionizing Radiation Protein Localization To Chromosome Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Double-strand Break Repair Telomere Organization DNA Recombination Nucleus Transcription Regulator Complex Site Of Double-strand Break Protein-containing Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Regulation Of Cell Cycle G2/M Phase Transition Response To X-ray Regulation Of Macromolecule Metabolic Process Response To Gamma Radiation Replication Fork DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Signal Transduction By P53 Class Mediator
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