GNAI2 and RGS16

Number of citations of the paper that reports this interaction (PubMedID 9079700)
0

Data Source:
HPRD (in vitro)

		GNAI2	RGS16
Description		G protein subunit alpha i2	regulator of G protein signaling 16
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 26955885 27494321 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	14 interacting genes: CREB3L2 CSK EGFR GDE1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAT1 LYN SRC ST14
Entrez ID		2771	6004
HPRD ID		00764	03945
Ensembl ID		ENSG00000114353	ENSG00000143333
Uniprot IDs		B3KP24 B3KX51 P04899	O15492
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV	2BT2 2IK8
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway GTPase Activity Nucleotide Binding GTP Binding G Protein Activity Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Membrane Protein Tyrosine Kinase Activity Adenylate Cyclase Regulator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Periphery T Cell Costimulation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Signaling Receptor Activator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GDP Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Signal Transduction Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signaling Phototransduction, Visible Light Regulation Of Catalytic Activity Extracellular Exosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Tyrosine Kinase Activator Activity Response To Peptide Hormone Response To Hormone Ciliary Basal Body Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Transport Regulation Of MAPK Cascade G Protein-coupled Acetylcholine Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway
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