GNAI2 and ADORA1

Number of citations of the paper that reports this interaction (PubMedID 11369591)
0

Data Source:
HPRD (in vivo)

		GNAI2	ADORA1
Description		G protein subunit alpha i2	adenosine A1 receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Dendrite Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Calyx Of Held Synapse Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding G Protein-coupled Receptor Activity Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Temperature Homeostasis Response To Hypoxia G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Response To Purine-containing Compound Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Dephosphorylation G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Vasodilation Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Cognition Leukocyte Migration Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Regulation Of Cardiac Muscle Contraction Excitatory Postsynaptic Potential Long-term Synaptic Depression Mucus Secretion Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Adenosine P1 receptors G alpha (i) signalling events
Drugs			Tramadol Caffeine Theophylline Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Cannabidiol Istradefylline Tonapofylline Rolofylline
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 27182965 30929738 31361310 31619474 31959851 32296059) Asthma (childhood onset) ( 30929738 31036433) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	12 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8 TSHR
Entrez ID		2771	134
HPRD ID		00764	00042
Ensembl ID		ENSG00000114353	ENSG00000163485
Uniprot IDs		B3KP24 B3KX51 P04899	B7Z1L9 B7Z379 P30542
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV	5N2S 5UEN 6D9H 7LD3 7LD4
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Dendrite G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Regulation Of Secretion Cell Body G Protein-coupled Dopamine Receptor Signaling Pathway Mu-type Opioid Receptor Binding Plasma Membrane G Protein-coupled Serotonin Receptor Binding Regulation Of Secretion By Cell System Process Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Negative Regulation Of Secretion By Cell Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission Postsynaptic Membrane G Protein-coupled Adenosine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Muscle System Process Regulation Of Hormone Secretion Regulation Of Body Fluid Levels Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway GTPase Activity Cellular Response To Catecholamine Stimulus Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway GTP Binding G Protein-coupled Receptor Activity Regulation Of Insulin Secretion Positive Regulation Of MAPK Cascade Regulation Of Exocytosis Locomotory Behavior Negative Regulation Of Synaptic Transmission Regulation Of Peptide Hormone Secretion Muscle Contraction Negative Regulation Of Insulin Secretion Regulation Of Hormone Levels Negative Regulation Of Peptide Secretion
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