GNAI2 and LTB4R

Number of citations of the paper that reports this interaction (PubMedID 17139258)
55

Data Source:
BioGRID (enzymatic study, pull down)

		GNAI2	LTB4R
Description		G protein subunit alpha i2	leukotriene B4 receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Nucleotide Binding Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Muscle Contraction Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Morniflumate Leukotriene B4
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	4 interacting genes: GNA15 GNAI2 GRK6 YWHAG
Entrez ID		2771	1241
HPRD ID		00764	03320
Ensembl ID		ENSG00000114353	ENSG00000213903
Uniprot IDs		B3KP24 B3KX51 P04899	Q15722
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV	7K15 7VKT
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	G Protein-coupled Acetylcholine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Adaptive Immune Response Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Regulation Of T Cell Mediated Immunity Memory T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T Cell Costimulation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Activation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Nematode Protein Kinase C Inhibitor Activity Signal Transduction Negative Regulation Of Lymphocyte Activation Beta-adrenergic Receptor Kinase Activity Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Negative Regulation Of Cell Activation Negative Regulation Of Regulatory T Cell Differentiation G Protein-coupled Receptor Kinase Activity Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of T Cell Activation Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion
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