GNAI2 and EDNRA

Number of citations of the paper that reports this interaction (PubMedID 7882989)
0

Data Source:
HPRD (in vivo)

		GNAI2	EDNRA
Description		G protein subunit alpha i2	endothelin receptor type A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Blood Vessel Remodeling Response To Amphetamine Regulation Of Heart Rate Heart Process Glomerular Filtration Cardiac Chamber Formation Left Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Mitochondrion Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Response To Wounding Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Artery Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Neuron Remodeling Heparin Proteoglycan Metabolic Process Thyroid Gland Development Neuron Projection Development Glomerulus Development Cellular Response To Oxidative Stress Embryonic Heart Tube Development Aorta Development Vasoconstriction Norepinephrine Metabolic Process Middle Ear Morphogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Human Chorionic Gonadotropin Stimulus Developmental Pigmentation Enteric Nervous System Development Sympathetic Nervous System Development Axon Extension Embryonic Skeletal System Development Neuromuscular Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Head Development Face Development Axonogenesis Involved In Innervation Establishment Of Endothelial Barrier Pharyngeal Arch Artery Morphogenesis Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Protein Transmembrane Transport Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Renal Albumin Absorption Vascular Associated Smooth Muscle Cell Development Mesenchymal Cell Apoptotic Process Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance CAMP/PKA Signal Transduction Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Podocyte Apoptotic Process Meiotic Cell Cycle Process Involved In Oocyte Maturation Cranial Skeletal System Development Response To Acetylcholine Regulation Of Protein Localization To Cell Leading Edge Positive Regulation Of Cation Channel Activity
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 33020668 24262325 32469254 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Lead levels ( 26025379) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878)
Interacting Genes		66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		2771	1909
HPRD ID		00764	00571
Ensembl ID		ENSG00000114353	ENSG00000151617
Uniprot IDs		B3KP24 B3KX51 P04899	P25101
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV	8HCQ 8XVI 8XVJ 8XVK 8XVL
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Urine Volume Endothelin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Urine Volume Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Blood Pressure Regulation Of Secretion By Cell G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Secretion Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Contraction Regulation Of Cell Differentiation Regulation Of Hormone Secretion Positive Regulation Of Cell Cycle Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Secretion By Cell Positive Regulation Of Muscle Contraction Postsynaptic Signal Transduction Neural Crest Cell Migration Neutrophil Chemotaxis Positive Regulation Of Secretion Mesenchymal Cell Migration Smooth Muscle Contraction Positive Regulation Of Cell Cycle Regulation Of Smooth Muscle Contraction Regulation Of Interleukin-2 Production Regulation Of Vasoconstriction Neutrophil Migration
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