GNAI2 and LHCGR

Number of citations of the paper that reports this interaction (PubMedID 10493819)
0

Data Source:
HPRD (in vivo)

		GNAI2	LHCGR
Description		G protein subunit alpha i2	luteinizing hormone/choriogonadotropin receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Endosome Plasma Membrane Membrane Centriolar Satellite
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Ovarian Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Cellular Response To Hormone Stimulus Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Gonadotropin Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cognition Uterus Development Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus Seminiferous Tubule Development Regulation Of Steroid Hormone Biosynthetic Process
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)
Diseases		Adrenal carcinoma	Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	A body shape index ( 34021172) Body mass index ( 28892062) Hip circumference adjusted for BMI ( 34021172) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128 22885925) Sex hormone-binding globulin levels ( 22829776) Triglyceride levels ( 32154731) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB NHERF1 TSHR
Entrez ID		2771	3973
HPRD ID		00764	01073
Ensembl ID		ENSG00000114353	ENSG00000138039
Uniprot IDs		B3KP24 B3KX51 P04899	P22888
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV	7FIG 7FIH 7FII 7FIJ
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	Pituitary Gonadotropin Complex G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Signaling Regulation Of Biological Quality Cell Communication Hormone Activity Guanyl Nucleotide Binding Renal System Process Secretion By Cell G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway Signal Transduction Heterotrimeric G-protein Complex Hormone Metabolic Process Regulation Of Hormone Levels Hormone Biosynthetic Process Postsynaptic Signal Transduction Acidic Amino Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Thyrotropin-releasing Hormone Renal Phosphate Ion Absorption Regulation Of ERK1 And ERK2 Cascade Angiotensin Receptor Binding G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Cellular Response To Hormone Stimulus Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Developmental Growth Positive Regulation Of Synaptic Transmission, Dopaminergic Golgi Lumen Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
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