GNAI2 and LHB

Number of citations of the paper that reports this interaction (PubMedID 8663226)
0

Data Source:
HPRD (in vitro)

		GNAI2	LHB
Description		G protein subunit alpha i2	luteinizing hormone subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Extracellular Region Extracellular Space Cytoplasm Golgi Lumen Pituitary Gonadotropin Complex
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Signaling Receptor Binding Hormone Activity Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Progesterone Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Hormone-mediated Signaling Pathway
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	7 interacting genes: CGA FHL3 GNAI2 GNAS LHCGR NTM SGTB
Entrez ID		2771	3972
HPRD ID		00764	01072
Ensembl ID		ENSG00000114353	ENSG00000104826
Uniprot IDs		B3KP24 B3KX51 P04899	A0A0F7RQE6 P01229
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	Guanyl Nucleotide Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Ovulation Cycle Process G Protein-coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Regulation Of Steroid Biosynthetic Process Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Negative Regulation Of Developmental Growth Regulation Of Steroid Metabolic Process Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Luteinizing Hormone Signaling Pathway TRC Complex Regulation Of Hormone Levels Renal System Process Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Animal Organ Development Gonad Development Development Of Secondary Male Sexual Characteristics Luteinizing Hormone Secretion Response To Hormone Hormone-mediated Signaling Pathway Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Cellular Response To Luteinizing Hormone Stimulus Regulation Of Inositol Trisphosphate Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Gonadotropin Secretion Regulation Of Lipid Biosynthetic Process Reproductive Structure Development Beta-2 Adrenergic Receptor Binding Development Of Secondary Sexual Characteristics D1 Dopamine Receptor Binding Response To Luteinizing Hormone Negative Regulation Of Growth Rhythmic Process Positive Regulation Of Urine Volume
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