PTOV1 and DMTN

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTOV1	DMTN
Gene Name		prostate tumor overexpressed 1	dematin actin binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytosol Actin Filament Plasma Membrane Endomembrane System Spectrin-associated Cytoskeleton Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Perinuclear Region Of Cytoplasm
	Molecular Function		Actin Binding Receptor Binding Protein Binding Spectrin Binding Protein Self-association
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Protein Complex Assembly Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DMTN GNB2L1 HDAC6 PIN1 SPTAN1 TMCC2 UBC USP16	13 interactors: ACTB ACTC1 APP DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB
Entrez ID		53635	2039
HPRD ID		17929	00506
Ensembl ID		ENSG00000104960	ENSG00000158856
Uniprot IDs		Q86YD1	B4DI75 Q08495
PDB IDs			1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Complex Assembly Negative Regulation Of Protein Complex Disassembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Depolymerization Regulation Of Protein Metabolic Process Regulation Of Protein Complex Disassembly Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Cytoskeleton Organization Regulation Of Cell Motility Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Organelle Organization Negative Regulation Of Type I Interferon Production Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Actin Filament Capping Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Phosphorylation Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Catabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Protein Polymerization Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Platelet Aggregation Hsp90 Deacetylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytoskeleton Organization Modification-dependent Protein Catabolic Process Cell Cycle Regulation Of Signal Transduction	Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Tight Junction Assembly Cellular Response To Epinephrine Stimulus Response To Epinephrine Blood Coagulation Regulation Of Protein Binding Cell Maturation Hemostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Cellular Response To Catecholamine Stimulus Platelet Activation Ion Homeostasis Regulation Of Body Fluid Levels Cell Development Negative Regulation Of Transporter Activity Negative Regulation Of Nucleotide Metabolic Process Wound Healing Chemotaxis Regulation Of Binding Locomotion Cell Activation Immune Response Response To Wounding Regulation Of Cell Junction Assembly Water Homeostasis Homeostatic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Innate Immune Response Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Membrane Organization Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Morphogenesis Response To Interleukin-1 Regulation Of Striated Muscle Contraction Regulation Of Phospholipase Activity Negative Regulation Of Protein Polymerization Axon Guidance Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Tagcloud ?		acquired cbp coactivator consistently cooperates cytotoxicity determinants dissociation far forming impaired mediates nucleus obscure obstacle promoting ra rar remained repression responsive retinoic retinoids ternary thereby trans translocating widely zyxin	apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Difference) ?		acquired cbp coactivator consistently cooperates cytotoxicity determinants dissociation far forming impaired mediates nucleus obscure obstacle promoting ra rar remained repression responsive retinoic retinoids ternary thereby trans translocating widely zyxin	apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Intersection) ?