PTOV1 and SGK2

Number of citations of the paper that reports this interaction (PubMedID 34654719)
60

Data Source:
BioGRID (enzymatic study)

		PTOV1	SGK2
Description		PTOV1 extended AT-hook containing adaptor protein	serum/glucocorticoid regulated kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Cell Growth Protein Phosphorylation Response To Oxidative Stress Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Weight ( 34074324)
Interacting Genes		18 interacting genes: CCR4 DMTN DYRK1A HDAC1 HDAC4 HDAC6 HUWE1 NCOR1 PBK PIN1 PRKCD RACK1 RBPJ SGK2 SPTAN1 TMCC2 UBC USP16	9 interacting genes: APP DAPK1 HIRIP3 IL3RA NEDD4 NEDD4L PDPK1 PMM2 PTOV1
Entrez ID		53635	10110
HPRD ID		17929	06348
Ensembl ID		ENSG00000104960	ENSG00000101049
Uniprot IDs		A0A0C4DGR2 M0QY25 Q86YD1	Q9HBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification Process Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Protein-containing Complex Assembly Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Transcription Repressor Complex Histone Deacetylase Activity Macromolecule Deacylation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Histone Deacetylase Binding Circadian Rhythm Nucleoplasm Tau Protein Binding Chromatin Organization Post-translational Protein Modification Regulation Of Phosphorus Metabolic Process Negative Regulation Of Actin Filament Polymerization Negative Regulation Of MAPK Cascade Negative Regulation Of Catabolic Process Regulation Of Supramolecular Fiber Organization Chromatin Remodeling Negative Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Type 2 Mitophagy Regulation Of Translational Elongation Response To Stress Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Depolymerization Regulation Of Organelle Organization Macromolecule Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation	Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Neuromuscular Junction Development Regulation Of Toll-like Receptor Signaling Pathway Receptor Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Organization DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Dendrite Morphogenesis Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process 3-phosphoinositide-dependent Protein Kinase Activity H2A-H2B Histone Complex Chaperone Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Transport Interleukin-3 Receptor Activity Channel Inhibitor Activity Regulation Of Potassium Ion Transport Phosphomannomutase Activity GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
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