PTOV1 and TMCC2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PTOV1	TMCC2
Gene Name		prostate tumor overexpressed 1	transmembrane and coiled-coil domain family 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Integral Component Of Membrane
	Molecular Function		Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419 19820697) Platelet counts ( 22139419)
Protein-Protein Interactions		8 interactors: DMTN GNB2L1 HDAC6 PIN1 SPTAN1 TMCC2 UBC USP16	26 interactors: AES AMOTL2 APP C6orf165 CCDC33 CDR2 DIP2A DPY30 EIF4E2 FAM161A FAM74A4 FAM90A1 FBF1 HGS HSPD1 IQUB KAT5 PRPF31 PTOV1 RHOXF2 UBA1 WT1-AS ZNF250 ZNF417 ZNF581 ZNF587
Entrez ID		53635	9911
HPRD ID		17929	11040
Ensembl ID		ENSG00000104960	ENSG00000133069
Uniprot IDs		Q86YD1	G5E963 O75069
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Complex Assembly Negative Regulation Of Protein Complex Disassembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Depolymerization Regulation Of Protein Metabolic Process Regulation Of Protein Complex Disassembly Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Cytoskeleton Organization Regulation Of Cell Motility Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Organelle Organization Negative Regulation Of Type I Interferon Production Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Actin Filament Capping Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Phosphorylation Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Catabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Protein Polymerization Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Platelet Aggregation Hsp90 Deacetylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytoskeleton Organization Modification-dependent Protein Catabolic Process Cell Cycle Regulation Of Signal Transduction	Regulation Of Gene Expression Gene Expression RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cilium Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process B Cell Cytokine Production Isotype Switching To IgG Isotypes Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury Nitrogen Compound Metabolic Process Positive Regulation Of Anoikis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nitrogen Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		acquired cbp coactivator consistently cooperates cytotoxicity determinants dissociation far forming impaired mediates nucleus obscure obstacle promoting ra rar remained repression responsive retinoic retinoids ternary thereby trans translocating widely zyxin	apoe apolipoprotein app appl dementin developmental disrupted dmtn drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai
Tagcloud (Difference) ?		acquired cbp coactivator consistently cooperates cytotoxicity determinants dissociation far forming impaired mediates nucleus obscure obstacle promoting ra rar remained repression responsive retinoic retinoids ternary thereby trans translocating widely zyxin	apoe apolipoprotein app appl dementin developmental disrupted dmtn drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai
Tagcloud (Intersection) ?