PTOV1 and USP16

Number of citations of the paper that reports this interaction (PubMedID 21090589)
41

Data Source:
BioGRID (unspecified method)

		PTOV1	USP16
Description		PTOV1 extended AT-hook containing adaptor protein	ubiquitin specific peptidase 16
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function		Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes		18 interacting genes: CCR4 DMTN DYRK1A HDAC1 HDAC4 HDAC6 HUWE1 NCOR1 PBK PIN1 PRKCD RACK1 RBPJ SGK2 SPTAN1 TMCC2 UBC USP16	23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2
Entrez ID		53635	10600
HPRD ID		17929	06881
Ensembl ID		ENSG00000104960	ENSG00000156256
Uniprot IDs		A0A0C4DGR2 M0QY25 Q86YD1	Q9Y5T5
PDB IDs			2I50 8WG5
Enriched GO Terms of Interacting Partners?		Protein Modification Process Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Protein-containing Complex Assembly Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Transcription Repressor Complex Histone Deacetylase Activity Macromolecule Deacylation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Histone Deacetylase Binding Circadian Rhythm Nucleoplasm Tau Protein Binding Chromatin Organization Post-translational Protein Modification Regulation Of Phosphorus Metabolic Process Negative Regulation Of Actin Filament Polymerization Negative Regulation Of MAPK Cascade Negative Regulation Of Catabolic Process Regulation Of Supramolecular Fiber Organization Chromatin Remodeling Negative Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Type 2 Mitophagy Regulation Of Translational Elongation Response To Stress Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Depolymerization Regulation Of Organelle Organization Macromolecule Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation	Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus
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