PTOV1 and CCR4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PTOV1	CCR4
Description		PTOV1 extended AT-hook containing adaptor protein	C-C motif chemokine receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function		G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Mogamulizumab FLX475
Diseases
GWAS			Asthma ( 31959851) Celiac disease ( 20190752 22057235) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		18 interacting genes: CCR4 DMTN DYRK1A HDAC1 HDAC4 HDAC6 HUWE1 NCOR1 PBK PIN1 PRKCD RACK1 RBPJ SGK2 SPTAN1 TMCC2 UBC USP16	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		53635	1233
HPRD ID		17929	05324
Ensembl ID		ENSG00000104960	ENSG00000183813
Uniprot IDs		A0A0C4DGR2 M0QY25 Q86YD1	A0N0Q1 P51679
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification Process Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Protein-containing Complex Assembly Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Transcription Repressor Complex Histone Deacetylase Activity Macromolecule Deacylation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Histone Deacetylase Binding Circadian Rhythm Nucleoplasm Tau Protein Binding Chromatin Organization Post-translational Protein Modification Regulation Of Phosphorus Metabolic Process Negative Regulation Of Actin Filament Polymerization Negative Regulation Of MAPK Cascade Negative Regulation Of Catabolic Process Regulation Of Supramolecular Fiber Organization Chromatin Remodeling Negative Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Type 2 Mitophagy Regulation Of Translational Elongation Response To Stress Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Depolymerization Regulation Of Organelle Organization Macromolecule Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation	Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response
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