SAE1 and UBE2E3

Number of citations of the paper that reports this interaction (PMID 10187858)
58

Data Source:
HPRD (in vivo, in vitro)

		SAE1	UBE2E3
Gene Name		SUMO1 activating enzyme subunit 1	ubiquitin-conjugating enzyme E2E 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	Celiac disease ( 20190752) Obesity ( 21552555)
Protein-Protein Interactions		15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39	75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4
Entrez ID		10055	10477
HPRD ID		18010	05000
Ensembl ID		ENSG00000142230	ENSG00000170035
Uniprot IDs		Q9UBE0	Q969T4
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle
Tagcloud ?			conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Difference) ?			conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Intersection) ?