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SAE1 and USP39
Number of citations of the paper that reports this interaction (PMID
25027693
)
0
Data Source:
BioGRID
(enzymatic study)
SAE1
USP39
Gene Name
SUMO1 activating enzyme subunit 1
ubiquitin specific peptidase 39
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
SUMO Activating Enzyme Complex
Intracellular Membrane-bounded Organelle
Spliceosomal Complex
Molecular Function
Ubiquitin Activating Enzyme Activity
Protein Binding
Protein C-terminus Binding
Enzyme Activator Activity
SUMO Activating Enzyme Activity
ATP-dependent Protein Binding
Protein Heterodimerization Activity
Zinc Ion Binding
Ubiquitinyl Hydrolase Activity
Biological Process
Regulation Of Mitotic Cell Cycle
Protein Ubiquitination
Protein Sumoylation
SMT3-dependent Protein Catabolic Process
Positive Regulation Of Catalytic Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Spliceosomal Complex Assembly
MRNA Processing
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
RNA Splicing
Cell Division
Pathways
Post-translational protein modification
SUMOylation
SUMO is conjugated to E1 (UBA2:SAE1)
Processing and activation of SUMO
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS
Multiple sclerosis (
21833088
)
Protein-Protein Interactions
15 interactors:
APP
ETV4
HSPA1A
HSPA2
IL3RA
PTK2
RANBP2
SP100
SUMO1
SUMO2
SUMO3
UBA2
UBE2E3
UBE2I
USP39
11 interactors:
ACVR1
APP
SAE1
SP1
SRPK1
TRAF6
TRIM25
TRIM26
TRIM39
TRIM5
TRIM8
Entrez ID
10055
10713
HPRD ID
18010
07165
Ensembl ID
ENSG00000142230
ENSG00000168883
Uniprot IDs
Q9UBE0
B3KMG1
B7Z7L9
Q53GS9
PDB IDs
1Y8Q
1Y8R
3KYC
3KYD
Enriched GO Terms of Interacting Partners
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Protein Sumoylation
Peptidyl-lysine Modification
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Peptidyl-amino Acid Modification
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Inclusion Body Assembly
Cellular Protein Modification Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Inclusion Body Assembly
Cellular Metabolic Process
Protein Refolding
Regulation Of Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Cytokine-mediated Signaling Pathway
Regulation Of Metabolic Process
Protein Localization To Nucleus
Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Viral Process
Cellular Response To Cytokine Stimulus
Negative Regulation Of DNA Binding
Response To Organic Substance
Regulation Of Growth
Regulation Of Binding
Synaptonemal Complex Disassembly
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of SUMO Transferase Activity
Protein Folding
Response To Cytokine
Nuclear Envelope Organization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Kinase Activity
Regulation Of Synapse Structure Or Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
SMT3-dependent Protein Catabolic Process
Negative Regulation Of Viral Release From Host Cell
Regulation Of Viral Process
Negative Regulation Of Viral Entry Into Host Cell
Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Process
Regulation Of Viral Release From Host Cell
Defense Response
Innate Immune Response
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Immune Response
Cellular Response To Interferon-gamma
Immune System Process
Cellular Protein Modification Process
Response To Interferon-gamma
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cytokine-mediated Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Metabolic Process
Negative Regulation Of Locomotion
Cellular Response To Cytokine Stimulus
Regulation Of Signal Transduction
Cellular Response To Organic Substance
Negative Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Cellular Protein Metabolic Process
Response To Cytokine
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of RNA Metabolic Process
Response To Stress
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Response To Organic Substance
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Atrial Septum Development
Signal Transduction
Regulation Of Activin Receptor Signaling Pathway
Protein Metabolic Process
Viral Process
Signaling
Cell Communication
Protein K63-linked Ubiquitination
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
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