SAE1 and HSPA2

Number of citations of the paper that reports this interaction (PMID 25027693)
0

Data Source:
BioGRID (enzymatic study)

		SAE1	HSPA2
Gene Name		SUMO1 activating enzyme subunit 1	heat shock 70kDa protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Mitochondrion Cytosol Cell Surface Membrane CatSper Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity	Protein Binding ATP Binding Enzyme Binding Unfolded Protein Binding Glycolipid Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Response To Unfolded Protein Male Meiosis Male Meiosis I Spermatid Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)	HSF1-dependent transactivation Attenuation phase Meiotic synapsis Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39	9 interactors: APP CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38
Entrez ID		10055	3306
HPRD ID		18010	07174
Ensembl ID		ENSG00000142230	ENSG00000126803
Uniprot IDs		Q9UBE0	P54652
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD	3I33 4FSV
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process	Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Cellular Protein Metabolic Process Activation Of MAPKK Activity Neuron Death Cellular Protein Modification Process Pronuclear Fusion Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Modification-dependent Protein Catabolic Process SMT3-dependent Protein Catabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Poly-ADP-ribosylation Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Positive Regulation Of Protein Ubiquitination Activation Of MAPK Activity Regulation Of Growth Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Import Into Nucleus Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?			1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
Tagcloud (Difference) ?			1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
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