SAE1 and PAX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAE1	PAX8
Description		SUMO1 activating enzyme subunit 1	paired box 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Enzyme Activator Activity Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Protein Targeting To Mitochondrion	Urogenital System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Sensory Organ Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development S-shaped Body Morphogenesis Kidney Epithelium Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Formation of intermediate mesoderm Formation of the nephric duct
Drugs
Diseases			Congenital nongoitrous hypothyroidism (CHNG) Thyroid cancer
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 27863252 32888494)	Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Cervical intraepithelial neoplasia grade 3 ( 33794208) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Language functional connectivity ( 34929384) Lymphocyte count ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		22 interacting genes: AGTR1 APP CEBPA CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39	24 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HNF1B HOXC8 HOXC9 ID2 LONRF1 NFIC NFIX NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SMAD3 SS18L1 WBP2
Entrez ID		10055	7849
HPRD ID		18010	01335
Ensembl ID		ENSG00000142230	ENSG00000125618
Uniprot IDs		Q9UBE0	Q06710 R9W7C9
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ 6XOG 6XOH 6XOI 8VY5	2K27
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Nucleus Protein Sumoylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Post-translational Protein Modification Positive Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Small Protein Activating Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Protein Heterodimerization Activity Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis HMG Box Domain Binding Protein Modification Process Negative Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process DNA Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity DNA-templated Transcription Sequence-specific DNA Binding Chromatin Binding SUMO Transferase Activity	Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Animal Organ Morphogenesis Regulation Of Primary Metabolic Process Chromatin Pattern Specification Process Positive Regulation Of Metabolic Process Regionalization Anterior/posterior Pattern Specification Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thigmotaxis Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Endoderm Development Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Organ Morphogenesis DNA-binding Transcription Factor Activity Gland Development Mesonephric Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Mesonephric Epithelium Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Tube Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Kidney Epithelium Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Virus Developmental Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Differentiation Response To Virus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding
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