SAE1 and UBD

Number of citations of the paper that reports this interaction (PubMedID 31575873)
61

Data Source:
BioGRID (pull down)

		SAE1	UBD
Description		SUMO1 activating enzyme subunit 1	ubiquitin like modifier D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Enzyme Activator Activity Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity	Protein Binding Proteasome Binding
	Biological Process	Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Protein Targeting To Mitochondrion	Proteolysis Ubiquitin-dependent Protein Catabolic Process Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Type II Interferon Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Neddylation
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 27863252 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		22 interacting genes: AGTR1 APP CEBPA CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39	29 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMD2 PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16
Entrez ID		10055	10537
HPRD ID		18010	09354
Ensembl ID		ENSG00000142230	ENSG00000213886
Uniprot IDs		Q9UBE0	A0A1U9X8S6 O15205
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ 6XOG 6XOH 6XOI 8VY5	2MBE 6GF1 6GF2 7PYV 9E8O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Nucleus Protein Sumoylation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Post-translational Protein Modification Positive Regulation Of Cell Differentiation Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Modification By Small Protein Conjugation Small Protein Activating Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Biosynthetic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Protein Heterodimerization Activity Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis HMG Box Domain Binding Protein Modification Process Negative Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process DNA Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity DNA-templated Transcription Sequence-specific DNA Binding Chromatin Binding SUMO Transferase Activity	Proteasome Core Complex Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Protein Catabolic Process Protein Metabolic Process Proteasome Core Complex, Beta-subunit Complex Nucleoplasm Catabolic Process Macromolecule Metabolic Process Nucleus Cytosol Extracellular Exosome Threonine-type Endopeptidase Activity Ubiquitin-like Modifier Activating Enzyme Activity Secretory Granule Lumen Ficolin-1-rich Granule Lumen SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Cytoplasm Ubiquitin Activating Enzyme Activity Endopeptidase Activity Small Protein Activating Enzyme Binding Protein Modification Process Post-translational Protein Modification Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Protein Sumoylation Proteasome Accessory Complex P-body Regulation Of Protein Sumoylation Regulation Of Post-translational Protein Modification Peptidase Activity Protein Modification By Small Protein Conjugation Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin Conjugating Enzyme Activity Lipopolysaccharide Binding Purine Ribonucleoside Triphosphate Binding Positive Regulation Of Ribosome Biogenesis FAT10 Activating Enzyme Activity Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication
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