SAE1 and ETV4

Number of citations of the paper that reports this interaction (PMID 19307308)
22

Data Source:
BioGRID (enzymatic study)

		SAE1	ETV4
Gene Name		SUMO1 activating enzyme subunit 1	ets variant 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle	Nucleolus
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Motor Neuron Axon Guidance Cell Differentiation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39	11 interactors: APP ATXN1 EP300 HOXD4 HTT JUN SAE1 SRF STK11 SUMO1 UBA2
Entrez ID		10055	2118
HPRD ID		18010	02833
Ensembl ID		ENSG00000142230	ENSG00000175832
Uniprot IDs		Q9UBE0	P43268
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process	Learning Positive Regulation Of Metabolic Process Associative Learning Learning Or Memory Cognition Response To Abiotic Stimulus Protein Sumoylation SMT3-dependent Protein Catabolic Process Response To Radiation Single-organism Behavior Regulation Of Cell Cycle Visual Learning Regulation Of Metabolic Process Visual Behavior Behavior Peptidyl-lysine Modification Regulation Of Binding Positive Regulation By Host Of Viral Transcription Positive Thymic T Cell Selection Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Neuron Development Apoptotic Process Thymic T Cell Selection Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Localization To Nucleus Circadian Rhythm Cell Death Death Regulation Of Signal Transduction Developmental Process Positive T Cell Selection Cellular Response To Organic Substance Regulation Of Neuron Differentiation Neuron Differentiation Cellular Metabolic Process Post-translational Protein Modification Neurological System Process Interaction With Symbiont Organ Development Regulation Of Growth Locomotory Behavior Immune System Process T Cell Selection Negative Regulation Of Cell Proliferation
Tagcloud ?			array ccl7 developing distant downregulated ets itga7 kiss1 luminal lymphovascular messenger metastasis mmp2 mmp7 nr4a3 overexpressed overexpression predictor probability ribonucleic shorter sstr timp3 tissue tnbc triple upregulated variant verify
Tagcloud (Difference) ?			array ccl7 developing distant downregulated ets itga7 kiss1 luminal lymphovascular messenger metastasis mmp2 mmp7 nr4a3 overexpressed overexpression predictor probability ribonucleic shorter sstr timp3 tissue tnbc triple upregulated variant verify
Tagcloud (Intersection) ?