UBA2 and SERBP1

Number of citations of the paper that reports this interaction (PMID 16679534)
6

Data Source:
HPRD (in vivo, two hybrid)

		UBA2	SERBP1
Gene Name		ubiquitin-like modifier activating enzyme 2	SERPINE1 mRNA binding protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex	Nucleus Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Enzyme Activator Activity Transcription Factor Binding SUMO Activating Enzyme Activity Metal Ion Binding Protein Heterodimerization Activity	MRNA 3'-UTR Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Regulation Of Apoptotic Process Regulation Of MRNA Stability
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS			Crohn's disease ( 22412388)
Protein-Protein Interactions		15 interactors: BRIX1 ETV4 NEDD8 PARK7 RAD23B RANBP2 SAE1 SERBP1 SP100 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBE2I	20 interactors: APP CHD3 CSNK2A1 DAXX FBXO25 FXYD3 ITFG1 KAT2B PCAP PIAS1 PIAS3 PIAS4 PRMT8 TDG TERT TOPORS UBA2 UPF2 VAV2 VIM
Entrez ID		10054	26135
HPRD ID		11658	09570
Ensembl ID		ENSG00000126261	ENSG00000142864
Uniprot IDs		B3KWB9 Q9UBT2	Q5VU21 Q63HR1 Q8NC51
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD	3J3A
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Peptidyl-lysine Modification Regulation Of Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Protein Modification Process Regulation Of DNA Binding Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Negative Regulation Of Binding Cellular Macromolecule Catabolic Process Cytokine-mediated Signaling Pathway Protein Localization To Nucleus Proteolysis Regulation Of Protein Export From Nucleus Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Catabolic Process Negative Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process	Protein Sumoylation Peptidyl-lysine Modification Positive Regulation Of Protein Sumoylation RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Sumoylation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Chromatin Modification Protein Modification By Small Protein Conjugation Chromatin Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Chromosome Organization Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Cell Death Death Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Production Of SiRNA Involved In RNA Interference
Tagcloud ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i	9q altered cgi contexts experimentally explain familiar functionally give habp4 haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Difference) ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i	9q altered cgi contexts experimentally explain familiar functionally give habp4 haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Intersection) ?