UBA2 and SAE1

Number of citations of the paper that reports this interaction (PMID 10187858)
58

Data Source:
HPRD (in vitro, in vivo)

		UBA2	SAE1
Gene Name		ubiquitin-like modifier activating enzyme 2	SUMO1 activating enzyme subunit 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding Enzyme Activator Activity Transcription Factor Binding SUMO Activating Enzyme Activity Metal Ion Binding Protein Heterodimerization Activity	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity
	Biological Process	Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		15 interactors: BRIX1 ETV4 NEDD8 PARK7 RAD23B RANBP2 SAE1 SERBP1 SP100 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBE2I	15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39
Entrez ID		10054	10055
HPRD ID		11658	18010
Ensembl ID		ENSG00000126261	ENSG00000142230
Uniprot IDs		B3KWB9 Q9UBT2	Q9UBE0
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD	1Y8Q 1Y8R 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Peptidyl-lysine Modification Regulation Of Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Protein Modification Process Regulation Of DNA Binding Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Negative Regulation Of Binding Cellular Macromolecule Catabolic Process Cytokine-mediated Signaling Pathway Protein Localization To Nucleus Proteolysis Regulation Of Protein Export From Nucleus Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Catabolic Process Negative Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process	Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process
Tagcloud ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i
Tagcloud (Difference) ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i
Tagcloud (Intersection) ?