UBA2

Gene Name		ubiquitin-like modifier activating enzyme 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex
	Molecular Function	Protein Binding ATP Binding Enzyme Activator Activity Transcription Factor Binding SUMO Activating Enzyme Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS
Protein-protein Interactions		15 interactors: BRIX1 ETV4 NEDD8 PARK7 RAD23B RANBP2 SAE1 SERBP1 SP100 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBE2I
Entrez ID		10054
HPRD ID		11658
Ensembl ID		ENSG00000126261
Uniprot IDs		B3KWB9 Q9UBT2
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Peptidyl-lysine Modification Regulation Of Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Protein Catabolic Process Cellular Protein Modification Process Regulation Of DNA Binding Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Negative Regulation Of Binding Cellular Macromolecule Catabolic Process Cytokine-mediated Signaling Pathway Protein Localization To Nucleus Proteolysis Regulation Of Protein Export From Nucleus Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Catabolic Process Negative Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		16q12 2i abrogates anus aos1 brocks cerevisiae chromocenters conjugating covalently dominantly ears gst heterochromatin inherited localize malformations modifier pin2 polymeric pull sall1 sumo sumoylation tbs thumbs townes ubc9 ube2i