UBA2 and BRIX1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBA2	BRIX1
Description		ubiquitin like modifier activating enzyme 2	biogenesis of ribosomes BRX1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm SUMO Activating Enzyme Complex	Nucleus Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding RRNA Binding
	Biological Process	Protein Sumoylation Positive Regulation Of Protein Sumoylation	Ribosomal Large Subunit Assembly RRNA Processing Ribosome Biogenesis
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS
Interacting Genes		19 interacting genes: BRIX1 CEBPA CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SETX SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I	5 interacting genes: CD48 GSK3B SETDB1 UBA2 UNC119
Entrez ID		10054	55299
HPRD ID		11658	16563
Ensembl ID		ENSG00000126261	ENSG00000113460
Uniprot IDs		Q9UBT2	Q8TDN6
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ 6XOG 6XOH 6XOI	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Small Protein Activating Enzyme Binding Protein Sumoylation Protein Modification By Small Protein Conjugation PML Body Post-translational Protein Modification Nucleus Ubiquitin-like Protein Ligase Binding PML Body Organization Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Nuclear Body Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Nucleus Organization Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Metabolic Process DNA Repair Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Binding DNA Damage Response Proteasome Binding Negative Regulation Of DNA Binding Ubiquitin-specific Protease Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Sumoylation Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Nucleolus Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Metabolic Process	Positive Regulation Of Post-translational Protein Modification Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Protein Modification Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Protein Modification Process Negative Regulation Of Caveolin-mediated Endocytosis SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Clathrin-dependent Endocytosis Histone H3K9 Trimethyltransferase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Cellular Response To Interleukin-3 Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Localization To Centrosome Regulation Of Caveolin-mediated Endocytosis Histone H3K9 Monomethyltransferase Activity Ubiquitin-like Protein Conjugating Enzyme Binding Small Protein Activating Enzyme Binding Negative Regulation Of Glycogen Biosynthetic Process ER Overload Response Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Binding Regulation Of Mesenchymal Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Methyltransferase Activity Ubiquitin-like Modifier Activating Enzyme Activity SUMO Binding Beta-catenin Destruction Complex Regulation Of Protein Localization To Centrosome Heterochromatin Organization Wnt Signalosome Regulation Of TORC2 Signaling Positive Regulation Of Protein Sumoylation TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cellular Response To Heat Maintenance Of Cell Polarity Protein Kinase A Catalytic Subunit Binding
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