UBA2 and RAD23B

Number of citations of the paper that reports this interaction (PubMedID 22863883)
24

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		UBA2	RAD23B
Description		ubiquitin like modifier activating enzyme 2	RAD23 nucleotide excision repair protein B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm SUMO Activating Enzyme Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol XPC Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Metal Ion Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Proteasome Binding DNA Damage Sensor Activity
	Biological Process	Protein Sumoylation Positive Regulation Of Protein Sumoylation	DNA Repair Nucleotide-excision Repair DNA Damage Response Spermatogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Cellular Response To Interleukin-7
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Body mass index ( 20966902) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 21263130) Chronotype ( 30696823) Cutaneous malignant melanoma ( 26237428) Melanoma ( 28212542) Prostate cancer ( 23023329)
Interacting Genes		19 interacting genes: BRIX1 CEBPA CHEK1 ERCC6 ETV4 MEOX2 NEDD8 PARK7 RAD23B SAE1 SERBP1 SETX SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBD UBE2I	31 interacting genes: ADRM1 ATXN3 CALM1 CEBPA DBI DEAF1 HIP1 HMGB1 MKRN1 MLH1 MPG NGLY1 OGT PAQR3 PAX3 PNMA5 POU6F2 PSMD4 PUF60 RPA1 RSC1A1 TAX1BP1 TDG UBA2 UBB UBC UBE3A USP25 WWP2 XPC ZFAND5
Entrez ID		10054	5887
HPRD ID		11658	06772
Ensembl ID		ENSG00000126261	ENSG00000119318
Uniprot IDs		Q9UBT2	B7Z4W4 P54727
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ 6XOG 6XOH 6XOI	1P1A 1PVE 1UEL 8EBS 8EBV 8EBW
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Small Protein Activating Enzyme Binding Protein Sumoylation Protein Modification By Small Protein Conjugation PML Body Post-translational Protein Modification Nucleus Ubiquitin-like Protein Ligase Binding PML Body Organization Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Nuclear Body Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Nucleus Organization Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Metabolic Process DNA Repair Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Binding DNA Damage Response Proteasome Binding Negative Regulation Of DNA Binding Ubiquitin-specific Protease Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Sumoylation Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Nucleolus Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Metabolic Process	Nucleus Macromolecule Metabolic Process Damaged DNA Binding Base-excision Repair SUMO Binding Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Proteolysis Nucleoplasm Modification-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Mismatch Repair Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis DNA Repair Condensed Chromosome Single-stranded DNA Binding Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Bubble DNA Binding Protein Ubiquitination Protein Catabolic Process Nucleic Acid Metabolic Process Nucleotide-excision Repair DNA N-glycosylase Activity Protein Polyubiquitination Mismatched DNA Binding Proteasomal Protein Catabolic Process Proteasome Complex Positive Regulation Of TORC1 Signaling Protein Metabolic Process DNA Metabolic Process Protein Tag Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Base-excision Repair, AP Site Formation Protein Modification Process DNA Damage Response Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Protein Binding Regulation Of Primary Metabolic Process DNA Binding Regulation Of TORC1 Signaling Cell Development
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