WASHC1 and PRKAA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WASHC1	PRKAA2
Description		WASH complex subunit 1	protein kinase AMP-activated catalytic subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Centriole Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Ciliary Basal Body Neuronal Cell Body
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding Gamma-tubulin Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity
	Biological Process	Exocytosis Negative Regulation Of Autophagy Protein Transport Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Ubiquitination Endocytic Recycling Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi	Cytoplasmic Translation Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Sterol Biosynthetic Process Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Rhythmic Process Fatty Acid Homeostasis Protein Localization To Lysosome Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs Nuclear events mediated by NFE2L2 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS			Lymphocyte count ( 22286170)
Interacting Genes		54 interacting genes: ABI2 ABI3 ATPAF2 BECN1 BLOC1S2 C14orf119 C1orf216 CDR2L CEP55 EIF3F EXOC8 FHL2 GYS1 HGS HSBP1 HSF2BP IFT57 KANK2 KLC3 KRT20 KRT26 KRT28 KRT3 KRT75 KRT76 LIMK1 LMO1 LMO2 LMO3 LMO4 MORN4 MRFAP1 NDC80 NUP62CL OIP5 OSTF1 POLR1C PRKAA2 RABGEF1 RNF2 SDCBP SMARCD1 TPM1 TPM3 TRIM69 TSG101 TTC19 TXLNA UBL5 USP20 WASHC3 WASHC4 WASHC5 ZBTB16	122 interacting genes: ABI1 ABI2 ACACA ACACB AIMP2 AKAP8L AMOT AMOTL2 ANAPC11 APPBP2 ARRDC3 AVPI1 C19orf47 CALCOCO1 CALCOCO2 CCDC172 CCDC33 CCNB1IP1 CDC42EP1 CDR2 CDX4 CPSF7 CTAG2 CYSRT1 DNAAF6 DNM2 DNMT1 DVL3 EEF2K EMILIN1 EPM2A EPN2 FNDC3B FOS GIGYF1 GLI1 GOLGA2 GOLGA6A GRAP2 HAT1 HMBOX1 HNF4A HOMEZ IKZF1 IKZF3 KCTD1 KCTD9 KIAA1328 KIF16B KIF24 KIFC3 KRT16 KRT31 KRTAP1-3 KRTAP10-3 KRTAP10-9 L3MBTL3 LCN2 LEP LZTS2 MKRN3 MORN3 MRFAP1 MTUS2 MYCL MYOZ1 NAB2 NECAB2 NONO NOTCH2NLA NRAP NRBF2 NUTM1 PBXIP1 PFKFB2 PLEKHN1 PRDM6 PRKAB1 PRKAG1 PRKAR1B PRKN PRPH RASAL3 RBBP7 RBPMS REL RFX6 RPTOR SAXO4 SERTAD3 SKIC2 SLA2 SNW1 SOHLH1 SPRY1 STAC2 STK11 TCF4 TFAP2A TIFA TLE5 TMOD1 TRIP13 TRIP6 TSC22D4 UBC UBE2I USH1C USH1G USHBP1 VPS28 VPS37B VPS52 WASHC1 WWP1 WWP2 YPEL3 ZBTB8A ZMYND12 ZNF212 ZNF397 ZSCAN23
Entrez ID		100287171	5563
HPRD ID			02735
Ensembl ID		ENSG00000181404	ENSG00000162409
Uniprot IDs		A8K0Z3	P54646
PDB IDs			2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Cytoskeleton Organization Endosomal Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Protein Binding Regulation Of Actin Nucleation Endosome Organization Organelle Localization Intermediate Filament Regulation Of Organelle Organization Positive Regulation Of Exosomal Secretion WASH Complex Transport Along Microtubule Regulation Of Actin Filament Organization Regulation Of Exosomal Secretion Cytoskeleton Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Cellular Localization Intracellular Transport Muscle Thin Filament Tropomyosin Microtubule-based Transport Cytosol Regulation Of Actin Cytoskeleton Organization Axo-dendritic Transport Regulation Of Extracellular Exosome Assembly Actin Filament Organization Establishment Of Organelle Localization Establishment Of Localization In Cell Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Protein Localization To Vacuole Late Endosome To Vacuole Transport Cytoskeleton-dependent Cytokinesis Regulation Of Cytoskeleton Organization Identical Protein Binding Cytoplasm Nuclear Speck Membrane Fission Exocytosis Vesicle Organization Regulation Of Stress Granule Assembly Cell Division	Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cytosol Supramolecular Fiber Organization Cytoplasm Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Malonyl-CoA Biosynthetic Process Acetyl-CoA Carboxylase Activity Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Prolactin Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cytoskeleton Cellular Component Assembly Autophagy Regulation Of Growth Transcription Factor Binding Equilibrioception Keratin Filament Microtubule Motor Activity Cullin Family Protein Binding Microtubule
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?