WASHC1 and GYS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WASHC1	GYS1
Description		WASH complex subunit 1	glycogen synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Centriole Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex	Cytoplasm Cytosol Membrane Inclusion Body
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding Gamma-tubulin Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Catalytic Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Protein Binding D-glucose Binding Transferase Activity Glycosyltransferase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate
	Biological Process	Exocytosis Negative Regulation Of Autophagy Protein Transport Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Ubiquitination Endocytic Recycling Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi	Glycogen Metabolic Process Glycogen Biosynthetic Process Heart Development
Pathways			Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1)
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		54 interacting genes: ABI2 ABI3 ATPAF2 BECN1 BLOC1S2 C14orf119 C1orf216 CDR2L CEP55 EIF3F EXOC8 FHL2 GYS1 HGS HSBP1 HSF2BP IFT57 KANK2 KLC3 KRT20 KRT26 KRT28 KRT3 KRT75 KRT76 LIMK1 LMO1 LMO2 LMO3 LMO4 MORN4 MRFAP1 NDC80 NUP62CL OIP5 OSTF1 POLR1C PRKAA2 RABGEF1 RNF2 SDCBP SMARCD1 TPM1 TPM3 TRIM69 TSG101 TTC19 TXLNA UBL5 USP20 WASHC3 WASHC4 WASHC5 ZBTB16	43 interacting genes: AIMP2 APP BEND7 CCDC33 CDCA8 CLVS2 CRX CSNK2A1 EFHC2 FAM228A GSK3B GYG1 GYG2 HOXB6 HOXC8 IHO1 INCA1 KATNBL1 KLF1 KLF4 MAPKAPK5 MEOX1 NDUFB7 NHLRC1 PCYT1A PINX1 PLAGL2 PNMA5 PRKACA RBM48 SNIP1 SORBS3 SUMO2 TFAP2D TLE5 WASHC1 ZBTB33 ZNF212 ZNF326 ZNF474 ZNF552 ZNF620 ZNF774
Entrez ID		100287171	2997
HPRD ID			00721
Ensembl ID		ENSG00000181404	ENSG00000104812
Uniprot IDs		A8K0Z3	P13807
PDB IDs			7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Cytoskeleton Organization Endosomal Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Protein Binding Regulation Of Actin Nucleation Endosome Organization Organelle Localization Intermediate Filament Regulation Of Organelle Organization Positive Regulation Of Exosomal Secretion WASH Complex Transport Along Microtubule Regulation Of Actin Filament Organization Regulation Of Exosomal Secretion Cytoskeleton Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Cellular Localization Intracellular Transport Muscle Thin Filament Tropomyosin Microtubule-based Transport Cytosol Regulation Of Actin Cytoskeleton Organization Axo-dendritic Transport Regulation Of Extracellular Exosome Assembly Actin Filament Organization Establishment Of Organelle Localization Establishment Of Localization In Cell Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Protein Localization To Vacuole Late Endosome To Vacuole Transport Cytoskeleton-dependent Cytokinesis Regulation Of Cytoskeleton Organization Identical Protein Binding Cytoplasm Nuclear Speck Membrane Fission Exocytosis Vesicle Organization Regulation Of Stress Granule Assembly Cell Division	Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Glycogenin Glucosyltransferase Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Glycogen Biosynthetic Process Glycogen Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Polysaccharide Biosynthetic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Response To Endothelin Positive Regulation Of Apoptotic Process Regulation Of Post-translational Protein Modification Response To Endothelin Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Wnt Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Neuron Apoptotic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Laminar Fluid Shear Stress Regulation Of Cell Cycle Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Export From Nucleus
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