TANK and TP53BP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TANK	TP53BP2
Gene Name		TRAF family member-associated NFKB activator	tumor protein p53 binding protein 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response	Cell Cycle Signal Transduction Central Nervous System Development Heart Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Signal Transduction Response To Ionizing Radiation Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Dietary macronutrient intake ( 23372041) Educational attainment ( 23722424) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Subcutaneous adipose tissue ( 22589738) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		31 interactors: AIMP2 APBA3 APP ATP6V1H BIK CEP63 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCH5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRIM37 USP7 ZC3H12A	58 interactors: APP ATPAF2 ATXN7 BAIAP2 BCL2 BCL2L1 CCDC92 CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 HIST1H2BC HNRNPUL1 KIF5A LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRKAB2 PRPF31 PTN RELA SIAH1 SIAH2 SSX2IP SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26
Entrez ID		10010	7159
HPRD ID		04870	11803
Ensembl ID		ENSG00000136560	ENSG00000143514
Uniprot IDs		B2R7S3 Q6NW12 Q92844	Q13625
PDB IDs		1KZZ 1L0A	1YCS 2UWQ 4A63
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Apoptotic Process Viral Process Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Cellular Response To Tumor Necrosis Factor Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Innate Immune Response Response To Tumor Necrosis Factor Cellular Response To Stimulus I-kappaB Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cell Communication Signal Transduction Regulation Of Cellular Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Metabolic Process	Neuron Death Neuron Apoptotic Process Response To Radiation Regulation Of Signal Transduction Regulation Of Signaling Response To External Stimulus Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Apoptotic Signaling Pathway Cell Part Morphogenesis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Phosphorylation Response To Light Stimulus Protein Modification By Small Protein Conjugation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Neuron Projection Morphogenesis Regulation Of Mitochondrion Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Projection Morphogenesis Axonogenesis Cellular Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Protein Metabolic Process Response To Gamma Radiation Axon Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Generation Of Neurons Nervous System Development Cellular Response To Ionizing Radiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Innate Immune Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Neuron Projection Development Neurogenesis Anatomical Structure Morphogenesis
Tagcloud ?		benzene cargo census cleaning conditional crew deck gasoline haematopoietic haenszel hodgkin leukaemia lymphatic malignancies mantel nested operations ors petroleum record referent referents register registry seamen swedish tankers unloading vapours	adenovirus angiotensin apoptosis array at2r bag3 bmp6 bmp7 bnipi cytokine downregulation du145 gadd45a hrk il6 il8 mapk microrna next numerous p44 pc r2 silence sirnas tnfsf10 trail transduced utilized
Tagcloud (Difference) ?		benzene cargo census cleaning conditional crew deck gasoline haematopoietic haenszel hodgkin leukaemia lymphatic malignancies mantel nested operations ors petroleum record referent referents register registry seamen swedish tankers unloading vapours	adenovirus angiotensin apoptosis array at2r bag3 bmp6 bmp7 bnipi cytokine downregulation du145 gadd45a hrk il6 il8 mapk microrna next numerous p44 pc r2 silence sirnas tnfsf10 trail transduced utilized
Tagcloud (Intersection) ?