TANK and ZC3H12A

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TANK	ZC3H12A
Gene Name		TRAF family member-associated NFKB activator	zinc finger CCCH-type containing 12A
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding	Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response	Angiogenesis Apoptotic Process Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Cellular Response To Lipopolysaccharide Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Dietary macronutrient intake ( 23372041) Educational attainment ( 23722424) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Subcutaneous adipose tissue ( 22589738) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		31 interactors: AIMP2 APBA3 APP ATP6V1H BIK CEP63 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCH5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRIM37 USP7 ZC3H12A	13 interactors: AHSP AIMP2 BTRC CYFIP2 EP300 IKBKG IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK UBC
Entrez ID		10010	80149
HPRD ID		04870	08021
Ensembl ID		ENSG00000136560	ENSG00000163874
Uniprot IDs		B2R7S3 Q6NW12 Q92844	Q5D1E8
PDB IDs		1KZZ 1L0A	3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Apoptotic Process Viral Process Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Cellular Response To Tumor Necrosis Factor Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Innate Immune Response Response To Tumor Necrosis Factor Cellular Response To Stimulus I-kappaB Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cell Communication Signal Transduction Regulation Of Cellular Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Metabolic Process	I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Viral Process Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response-activating Signal Transduction Regulation Of Protein Stability Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response Regulation Of Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of Type I Interferon Production JNK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Protein Stabilization Regulation Of Type I Interferon Production Regulation Of Immune System Process Positive Regulation Of Cytokine Production Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Defense Response
Tagcloud ?		benzene cargo census cleaning conditional crew deck gasoline haematopoietic haenszel hodgkin leukaemia lymphatic malignancies mantel nested operations ors petroleum record referent referents register registry seamen swedish tankers unloading vapours	attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10
Tagcloud (Difference) ?		benzene cargo census cleaning conditional crew deck gasoline haematopoietic haenszel hodgkin leukaemia lymphatic malignancies mantel nested operations ors petroleum record referent referents register registry seamen swedish tankers unloading vapours	attached attenuating cascade ccch chains chemotactic consequences consistently deleterious deubiquitinase deubiquitination elucidated feedback finger genotoxic kappab linear mcpip1 mediating monocyte nemo polyubiquitin promotion serves signalling terminated ubiquitylation uncontrolled usp10
Tagcloud (Intersection) ?