NCK2 and KCTD17

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NCK2	KCTD17
Name		NCK adaptor protein 2	potassium channel tetramerization domain containing 17
Structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane Postsynaptic Density Synapse	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Cytoskeletal Anchor Activity Signaling Receptor Complex Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Scaffold Protein Binding	Protein Binding Identical Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immunological Synapse Formation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Response To Endoplasmic Reticulum Stress Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Dendritic Spine Development Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization
Pathways		Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching RHOU GTPase cycle RHOV GTPase cycle	None
GWAS		Addiction ( 23533358 ) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 ) Anti-chlamydia trachomatis IgG seropositivity ( 33204752 ) Mean platelet volume ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) Systolic blood pressure in sickle cell anemia ( 24058526 )	Hemoglobin levels ( 33491795 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Liver iron content ( 34128465 ) Mean corpuscular hemoglobin concentration ( 28453575 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet distribution width ( 32888494 ) Red blood cell traits ( 23222517 )
Interacting Genes		168 interacting genes: ABI1 ABI2 ABI3 ANKRD55 ANKS1B ARHGAP32 ATN1 AXIN1 AXL BCAR1 BCL11A BTG1 C4orf17 CBARP CBLB CCDC120 CCDC33 CD3E CHN1 CHN2 CIB1 CIPC CLEC17A CPSF6 CPSF7 CUEDC1 DDR1 DEFB124 DISC1 DLGAP4 DNM1 DOCK1 DOK1 DRAP1 DTX3 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EFS EGFR EIF3H ERBB2 ERBB3 ERBB4 FAM124A FAM47A FAM53C FAM83A FASLG FBXL19 FCRL2 FGFR1 FOSB FXR2 FYB1 GAB1 GAREM1 GGN HNRNPK HOMEZ HOXA1 HOXC4 HOXD8 HSF2BP ILK INCA1 INTS2 IRS1 KCTD17 KHDRBS1 KIAA0408 KIAA1217 KIT KLHL24 KLHL35 KPRP LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MBD6 MEOX2 MET MIA3 MNT MYPOP NCKIPSD NELFA NET1 NFKBID NHSL2 NPAS2 NPHS1 NR5A1 NTRK2 NUTM2F ONECUT3 PAK1 PBX4 PDGFRB PHETA1 PIK3AP1 PKD1 PKN2 PRDM6 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMD10 PTK2 RASSF7 RBBP8NL RBM26 REEP4 REL SCML2 SCX SF1 SF3A2 SF3B4 SHD SKAP2 SMARCB1 SNW1 SORBS2 SOS1 SPATA2L SPATC1L SPRY2 SRMS SRPK1 SRPK2 SSH3 SYNGAP1 SYNPO TCF4 TCP10L TMEM121 TNR TRIM27 TRIM41 TRIP6 TXK UBC USP32 VARS2 VPS37B WAS WASF1 WASL WBP11 WIPF2 ZBTB12 ZBTB42 ZBTB7B ZC2HC1A ZC2HC1B ZNF341 ZNF526 ZNF688	23 interacting genes: AQP1 CRK DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1
Entrez ID		8440	79734
HPRD ID		05378	07764
Ensembl ID		ENSG00000071051	ENSG00000100379
Uniprot IDs		A0A0S2Z4M6 E7ERP6 O43639	A0A087WX35 Q8N5Z5
PDB IDs		1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R	5A6R
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cell Migration SH3 Domain Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Activity Regulation Of Cell Projection Organization Identical Protein Binding Signaling Adaptor Activity Regulation Of Neuron Projection Development Signal Transduction Tube Morphogenesis Protein Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anchoring Junction Lamellipodium SCAR Complex Regulation Of RNA Metabolic Process Response To Growth Factor Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Receptor Complex Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Protein Kinase Binding Ephrin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cell Junction Organization Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Cellular Component Organization	Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding