NCK2 and HOXC4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NCK2	HOXC4
Gene Name		NCK adaptor protein 2	homeobox C4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane	Nucleus
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding
	Biological Process	Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Embryonic Organ Morphogenesis Cartilage Development
Pathways		Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Addiction ( 23533358)
Protein-Protein Interactions		80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B	11 interactors: ELMOD2 HTT NCK2 PRKDC PRMT5 PRMT6 RNF32 SOX10 SUV39H1 WHSC1L1 XRCC6
Entrez ID		8440	3221
HPRD ID		05378	00860
Ensembl ID		ENSG00000071051	ENSG00000273266
Uniprot IDs		E7ERP6 O43639	P09017 Q86TF7
PDB IDs		1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development	Histone Methylation Negative Regulation Of Cellular Metabolic Process Protein Methylation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Histone H4-R3 Methylation Regulation Of Metabolic Process Histone Modification Methylation Peptidyl-arginine N-methylation Peptidyl-amino Acid Modification Histone Arginine Methylation Double-strand Break Repair Via Nonhomologous End Joining Peptidyl-arginine Methylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process V(D)J Recombination Chromatin Modification Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Neural Plate Formation Telomere Maintenance Central Nervous System Development Positive Regulation Of Type I Interferon Production Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Lysine Methylation Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Methylation Response To Radiation Regulation Of Circadian Rhythm Response To Abiotic Stimulus RNA Metabolic Process Histone H3-R2 Methylation
Tagcloud ?		accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv	125b 181b 19a 20a 23b 30a aicda autoantibody bach2 bcl6 blimp csr cytidine dampened deaminase hypermutated hypermutation irf4 lpr mrl pax5 prdm1 rev1 shm silence switched underpin ung valproic
Tagcloud (Difference) ?		accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv	125b 181b 19a 20a 23b 30a aicda autoantibody bach2 bcl6 blimp csr cytidine dampened deaminase hypermutated hypermutation irf4 lpr mrl pax5 prdm1 rev1 shm silence switched underpin ung valproic
Tagcloud (Intersection) ?