NCK2 and WBP11

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NCK2	WBP11
Gene Name		NCK adaptor protein 2	WW domain binding protein 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity	Single-stranded DNA Binding Protein Binding Protein Phosphatase Type 1 Regulator Activity Poly(A) RNA Binding WW Domain Binding
	Biological Process	Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation	RRNA Processing MRNA Processing RNA Splicing Regulation Of Catalytic Activity
Pathways		Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Addiction ( 23533358)
Protein-Protein Interactions		80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B	28 interactors: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 NCK2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SRC TESC TRAF4 TRIP10 VIM WBP4
Entrez ID		8440	51729
HPRD ID		05378	18293
Ensembl ID		ENSG00000071051	ENSG00000084463
Uniprot IDs		E7ERP6 O43639	F5H721 Q9Y2W2
PDB IDs		1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development	Enzyme Linked Receptor Protein Signaling Pathway RNA Splicing Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus RNA Processing MRNA Splicing, Via Spliceosome Response To Growth Factor RNA Splicing, Via Transesterification Reactions MRNA Processing Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Cell Death Death Entrainment Of Circadian Clock By Photoperiod MRNA Metabolic Process T Cell Costimulation Triglyceride Catabolic Process Regulation Of Gene Expression Regulation Of Intracellular Estrogen Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Regulation Of Signal Transduction Regulation Of Cellular Process Acylglycerol Catabolic Process Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Axon Guidance Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Positive Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway System Development Response To Radiation Developmental Process Anatomical Structure Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Neuron Differentiation
Tagcloud ?		accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Difference) ?		accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Intersection) ?