FLNC and HIPK3

Number of citations: 54 (PubMedID 15231748)
Data Source: HPRD (two hybrid)

		FLNC	HIPK3
Name		filamin C	homeodomain interacting protein kinase 3
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity
Pathways		Cell-extracellular matrix interactions	None
Drugs		None	Fostamatinib
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	None
GWAS		Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597 ) Reading disability or specific language impairment (pleiotropy) ( 25065397 ) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397 )	Anger ( 24489884 ) Obese vs. thin ( 30677029 ) Sleep (1/3-day periodicity) ( 33075057 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX
Entrez ID		2318	10114
HPRD ID		00018	05111
Ensembl ID		ENSG00000128591	ENSG00000110422
Uniprot IDs		Q14315 Q59H94	A8KAE4 Q9H422
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0	7O7I 7O7J
GO Terms Enriched among Interactors		Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication	Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytosol Nucleoplasm Regulation Of Gene Expression RNA Splicing Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein Kinase B Binding Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Signal Transduction Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome MRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cellular Response To Sodium Arsenite Double-stranded Methylated DNA Binding Small Protein Activating Enzyme Binding Regulation Of RNA Splicing Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding