NR1H4 and CASP8

Number of citations of the paper that reports this interaction (PMID 11733517)
30

Data Source:
HPRD (in vitro)

		NR1H4	CASP8
Gene Name		nuclear receptor subfamily 1, group H, member 4	caspase 8, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Euchromatin	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Noc1p-Noc2p Complex Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Bile Acid Binding Bile Acid Receptor Activity Peptide Binding Sequence-specific DNA Binding Retinoid X Receptor Binding Chenodeoxycholic Acid Binding	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Death Effector Domain Binding Protein Heterodimerization Activity Scaffold Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter Regulation Of Carbohydrate Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Bile Acid Metabolic Process Response To Glucose Gene Expression Intracellular Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Urea Metabolic Process Intracellular Bile Acid Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Regulation Of Bile Acid Biosynthetic Process Negative Regulation Of Bile Acid Biosynthetic Process Cellular Response To Organonitrogen Compound Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle	Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Cold Viral Process Natural Killer Cell Activation Macrophage Differentiation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Response To Antibiotic Protein Heterooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Regulation Of Thymocyte Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Hepatocyte Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		PPARA activates gene expression Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TRAIL signaling Death Receptor Signalling Caspase-8 activation by cleavage FasL/ CD95L signaling Activation, myristolyation of BID and translocation to mitochondria Caspase-mediated cleavage of cytoskeletal proteins Activated TLR4 signalling NOD1/2 Signaling Pathway Programmed Cell Death TRIF-mediated programmed cell death Innate Immune System Intrinsic Pathway for Apoptosis Regulation by c-FLIP Apoptotic cleavage of cellular proteins Dimerization of procaspase-8 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway
Drugs		Fexaramine Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
Diseases
GWAS		Squamous cell carcinoma ( 23341777)	Melanoma ( 21983787)
Protein-Protein Interactions		16 interactors: CASP8 EP300 ESR1 GAPDH HIST1H3A HIST1H4A NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRG SIRT1 SMARCD1 SMARCD3 SRC	91 interactors: APAF1 APP AR ATG4D BCAP31 BCL2 BCL2L1 BFAR BID BIRC6 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CDH1 CDK11B CDKN1B CFLAR CHD3 CHUK COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 FADD FAF1 FAS FYN GMEB1 GRIA1 GZMB HDAC7 HECTD3 HIP1 IKBKB IKBKG ILK KRT18 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 PARK2 PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PLA2G4B PLEC PLIN4 PRDX6 PRKCI PRKCZ PSEN1 PSEN2 RALBP1 RB1 RIPK1 RIPK2 RYBP SNRPD3 SRF STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 USO1 VIM
Entrez ID		9971	841
HPRD ID		04827	03459
Ensembl ID		ENSG00000012504	ENSG00000064012
Uniprot IDs		B6ZGS9 F1DAL1 Q96RI1	Q14790
PDB IDs		1OSH 1OSK 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4II6	1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Response To Hormone Positive Regulation Of Transcription, DNA-templated Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Response To Lipid Transcription Initiation From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Regulation Of Metabolic Process Reproductive Structure Development Reproductive System Development Heart Development Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Cardiovascular System Development Organelle Organization Negative Regulation Of Gene Expression Chromatin Modification Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Chromatin Silencing At RDNA Response To Estrogen Developmental Process Involved In Reproduction Intracellular Estrogen Receptor Signaling Pathway Organ Development Transcription, DNA-templated Single Organism Reproductive Process RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Lipid Metabolic Process Transcription From RNA Polymerase II Promoter	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Signal Transduction Regulation Of Peptidase Activity Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signaling Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Execution Phase Of Apoptosis Negative Regulation Of Cell Death Regulation Of Metabolic Process
Tagcloud ?		bile carcinogenic carcinomas colon concurred defense embedded farnesoid favourable fixed formalin fxr gradient grading gradually ileum intestinal inverse inversely ki mapping mucosa nonneoplastic paraffin peritumoral reflect seem sigmoid strongest	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Difference) ?		bile carcinogenic carcinomas colon concurred defense embedded farnesoid favourable fixed formalin fxr gradient grading gradually ileum intestinal inverse inversely ki mapping mucosa nonneoplastic paraffin peritumoral reflect seem sigmoid strongest	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Intersection) ?