NR1H4

Description		nuclear receptor subfamily 1 group H member 4
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GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Speck Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Bile Acid Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Chenodeoxycholic Acid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Cell-cell Junction Assembly Notch Signaling Pathway Bile Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Low-density Lipoprotein Particle Clearance Bile Acid And Bile Salt Transport Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-17 Production Toll-like Receptor 9 Signaling Pathway Regulation Of Urea Metabolic Process Intracellular Triglyceride Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Nuclear Receptor-mediated Bile Acid Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Fatty Acid Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Triglyceride Homeostasis Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Fatty Acid Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols
Drugs		alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh Nidufexor Tropifexor
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Squamous cell carcinoma ( 23341777)
Novel Interacting Genes		1 novel interacting genes: APAF1
Interacting Genes		15 interacting genes: CASP8 EP300 ESR1 GAPDH GRIN1 H3C1 NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRG SIRT1 SMARCD1 SMARCD3
Entrez ID		9971
HPRD ID		04827
Ensembl ID		ENSG00000012504
Uniprot IDs		B6ZGS9 F1DAL1 Q96RI1
PDB IDs		1OSH 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4OIV 4QE8 4WVD 5IAW 5ICK 5Q0I 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q17 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5WZX 5Y1J 5Y44 5Y49 5YXB 5YXD 5YXJ 5YXL 5Z12 6A5W 6A5X 6A5Y 6A5Z 6A60 6HL0 6HL1 6ITM 7D42 7TRB 7VUE 8HBM 8HD3
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Transcription Coactivator Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Rhythmic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Retinoid X Receptor Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nuclear Steroid Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway Developmental Process Myeloid Cell Differentiation Response To Estradiol Regulation Of RNA Metabolic Process Nucleus Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Glucose Metabolic Process Chromatin Organization Transcription Coregulator Activity Nuclear Estrogen Receptor Binding Nucleobase-containing Compound Biosynthetic Process Regulation Of Multicellular Organismal Process Nervous System Development Cell Differentiation Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Hexose Metabolic Process
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