NR1H4 and SIRT1

Number of citations of the paper that reports this interaction (PMID 19883617)
55

Data Source:
BioGRID (enzymatic study)

		NR1H4	SIRT1
Gene Name		nuclear receptor subfamily 1, group H, member 4	sirtuin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Euchromatin	Nuclear Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nuclear Euchromatin Nuclear Heterochromatin Nucleolus Cytoplasm Mitochondrion PML Body RDNA Heterochromatin ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Bile Acid Binding Bile Acid Receptor Activity Peptide Binding Sequence-specific DNA Binding Retinoid X Receptor Binding Chenodeoxycholic Acid Binding	Core Promoter Sequence-specific DNA Binding P53 Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Keratin Filament Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter Regulation Of Carbohydrate Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Bile Acid Metabolic Process Response To Glucose Gene Expression Intracellular Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Urea Metabolic Process Intracellular Bile Acid Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Regulation Of Bile Acid Biosynthetic Process Negative Regulation Of Bile Acid Biosynthetic Process Cellular Response To Organonitrogen Compound Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle	Single Strand Break Repair Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Adaptive Immune Response DNA Replication DNA Repair Chromatin Organization Chromatin Silencing Establishment Of Chromatin Silencing Maintenance Of Chromatin Silencing Methylation-dependent Chromatin Silencing Transcription, DNA-templated RRNA Processing Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To Starvation Gene Expression Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Viral Process Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Protein Destabilization Positive Regulation Of Chromatin Silencing Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Response To Endoplasmic Reticulum Stress Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Regulation Of Bile Acid Biosynthetic Process Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Neuron Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence
Pathways		PPARA activates gene expression Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs		Fexaramine Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
Diseases
GWAS		Squamous cell carcinoma ( 23341777)
Protein-Protein Interactions		16 interactors: CASP8 EP300 ESR1 GAPDH HIST1H3A HIST1H4A NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRG SIRT1 SMARCD1 SMARCD3 SRC	47 interactors: AKT1 ARNTL BCL11A BHLHE41 CDK6 CSNK2B CTTN EP300 ESRRA FOS FOXO1 FOXO3 GAPDH HES1 HEY2 HIC1 HIST1H1B HIST1H3A HNF4A IRS2 MAPK8 MAPT MYCN NBN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARGC1A PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 SREBF1 STK11 STK4 TP53 UBE2I VDR
Entrez ID		9971	23411
HPRD ID		04827	08381
Ensembl ID		ENSG00000012504	ENSG00000096717
Uniprot IDs		B6ZGS9 F1DAL1 Q96RI1	A8K128 B0QZ35 E9PC49 Q96EB6
PDB IDs		1OSH 1OSK 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4II6	4I5I
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Response To Hormone Positive Regulation Of Transcription, DNA-templated Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Response To Lipid Transcription Initiation From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Regulation Of Metabolic Process Reproductive Structure Development Reproductive System Development Heart Development Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Cardiovascular System Development Organelle Organization Negative Regulation Of Gene Expression Chromatin Modification Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Chromatin Silencing At RDNA Response To Estrogen Developmental Process Involved In Reproduction Intracellular Estrogen Receptor Signaling Pathway Organ Development Transcription, DNA-templated Single Organism Reproductive Process RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Lipid Metabolic Process Transcription From RNA Polymerase II Promoter	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Cellular Response To Hormone Stimulus Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development Intracellular Receptor Signaling Pathway System Development Response To Hormone Response To Organic Substance Regulation Of Signaling Developmental Process RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Signaling Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process
Tagcloud ?		bile carcinogenic carcinomas colon concurred defense embedded farnesoid favourable fixed formalin fxr gradient grading gradually ileum intestinal inverse inversely ki mapping mucosa nonneoplastic paraffin peritumoral reflect seem sigmoid strongest	1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride
Tagcloud (Difference) ?		bile carcinogenic carcinomas colon concurred defense embedded farnesoid favourable fixed formalin fxr gradient grading gradually ileum intestinal inverse inversely ki mapping mucosa nonneoplastic paraffin peritumoral reflect seem sigmoid strongest	1alpha adipose adrenergic alternate atgl biogenesis catalyzed coactivator coregulator deacetylase deacetylation fatty identifies links lipase lipolysis mediates metabolism nad oxidative partner peroxisome pgc ppar presumed proliferator promote sirtuin triglyceride
Tagcloud (Intersection) ?