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NR1H4 and SMARCD1
Number of citations of the paper that reports this interaction (PMID
12917342
)
52
Data Source:
BioGRID
(pull down)
NR1H4
SMARCD1
Gene Name
nuclear receptor subfamily 1, group H, member 4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Nuclear Euchromatin
SWI/SNF Complex
NpBAF Complex
NBAF Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Thyroid Hormone Receptor Activity
Protein Binding
Zinc Ion Binding
Ligand-dependent Nuclear Receptor Binding
Bile Acid Binding
Bile Acid Receptor Activity
Peptide Binding
Sequence-specific DNA Binding
Retinoid X Receptor Binding
Chenodeoxycholic Acid Binding
Transcription Coactivator Activity
Protein Binding
Protein Complex Scaffold
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter
Regulation Of Carbohydrate Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Bile Acid Metabolic Process
Response To Glucose
Gene Expression
Intracellular Receptor Signaling Pathway
Response To Lipopolysaccharide
Regulation Of Urea Metabolic Process
Intracellular Bile Acid Receptor Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Digestive Tract Development
Regulation Of Bile Acid Biosynthetic Process
Negative Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Organonitrogen Compound
Regulation Of Cholesterol Metabolic Process
Cellular Response To Bile Acid
Positive Regulation Of Glutamate Metabolic Process
Positive Regulation Of Ammonia Assimilation Cycle
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Nervous System Development
Chromatin-mediated Maintenance Of Transcription
Pathways
PPARA activates gene expression
Bile acid and bile salt metabolism
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Biological oxidations
Synthesis of bile acids and bile salts
Orphan transporters
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Fatty acid, triacylglycerol, and ketone body metabolism
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Recycling of bile acids and salts
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Drugs
Fexaramine
Chenodeoxycholic acid
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
Diseases
GWAS
Squamous cell carcinoma (
23341777
)
Protein-Protein Interactions
16 interactors:
CASP8
EP300
ESR1
GAPDH
HIST1H3A
HIST1H4A
NCOA1
NCOA6
NCOR2
PPARGC1A
RXRA
RXRG
SIRT1
SMARCD1
SMARCD3
SRC
44 interactors:
ANP32B
APOA5
AR
C4BPA
CALCOCO2
CCDC85B
CDC5L
CDX2
CORO1A
DPF3
EGFL7
ESR1
FEZ1
FOS
GATA1
GCC1
HNRNPC
HSPB1
IGKC
JUN
KDM1A
KLF1
KRT15
KRT18
LDOC1
MED4
NME1
NONO
NR1H4
NR3C1
NUCB2
PAICS
PCBD1
PGR
PRDX1
PRMT6
RIF1
RPS29
SUV420H1
TNIP2
TP53
USHBP1
VPS37B
YWHAG
Entrez ID
9971
6602
HPRD ID
04827
03438
Ensembl ID
ENSG00000012504
ENSG00000066117
Uniprot IDs
B6ZGS9
F1DAL1
Q96RI1
Q96GM5
PDB IDs
1OSH
1OSK
3BEJ
3DCT
3DCU
3FLI
3FXV
3GD2
3HC5
3HC6
3L1B
3OKH
3OKI
3OLF
3OMK
3OMM
3OOF
3OOK
3P88
3P89
3RUT
3RUU
3RVF
4II6
Enriched GO Terms of Interacting Partners
?
Intracellular Receptor Signaling Pathway
Response To Hormone
Positive Regulation Of Transcription, DNA-templated
Chromatin Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Steroid Hormone
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Gene Expression
Response To Lipid
Transcription Initiation From RNA Polymerase II Promoter
Intracellular Steroid Hormone Receptor Signaling Pathway
Response To Organic Cyclic Compound
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Chromosome Organization
Regulation Of RNA Biosynthetic Process
DNA-templated Transcription, Initiation
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Regulation Of Metabolic Process
Reproductive Structure Development
Reproductive System Development
Heart Development
Regulation Of Nitrogen Compound Metabolic Process
Rhythmic Process
Cardiovascular System Development
Organelle Organization
Negative Regulation Of Gene Expression
Chromatin Modification
Positive Regulation Of Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Remodeling
Chromatin Silencing At RDNA
Response To Estrogen
Developmental Process Involved In Reproduction
Intracellular Estrogen Receptor Signaling Pathway
Organ Development
Transcription, DNA-templated
Single Organism Reproductive Process
RNA Biosynthetic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Lipid Metabolic Process
Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Gene Expression
Transcription, DNA-templated
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Macromolecule Biosynthetic Process
Biosynthetic Process
Regulation Of Apoptotic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Cell Death
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Chromatin Organization
Regulation Of Gene Expression
Cellular Response To Organic Substance
Response To Organic Substance
Developmental Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Cellular Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Regulation Of RNA Metabolic Process
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
System Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Transcription Initiation From RNA Polymerase II Promoter
Steroid Hormone Mediated Signaling Pathway
Negative Regulation Of Cell Death
Chromosome Organization
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Multicellular Organismal Development
DNA-templated Transcription, Initiation
Hormone-mediated Signaling Pathway
Regulation Of Cell Proliferation
Cellular Response To Hormone Stimulus
Regulation Of Cellular Process
Chromatin Modification
Tagcloud
?
bile
carcinogenic
carcinomas
colon
concurred
defense
embedded
farnesoid
favourable
fixed
formalin
fxr
gradient
grading
gradually
ileum
intestinal
inverse
inversely
ki
mapping
mucosa
nonneoplastic
paraffin
peritumoral
reflect
seem
sigmoid
strongest
Tagcloud (Difference)
?
bile
carcinogenic
carcinomas
colon
concurred
defense
embedded
farnesoid
favourable
fixed
formalin
fxr
gradient
grading
gradually
ileum
intestinal
inverse
inversely
ki
mapping
mucosa
nonneoplastic
paraffin
peritumoral
reflect
seem
sigmoid
strongest
Tagcloud (Intersection)
?