MTAP and FOLH1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MTAP	FOLH1
Gene Name		methylthioadenosine phosphorylase	folate hydrolase (prostate-specific membrane antigen) 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome	Cytoplasm Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphorylase Activity S-methyl-5-thioadenosine Phosphorylase Activity	Carboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Dipeptidase Activity Metal Ion Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Polyamine Metabolic Process Nicotinamide Riboside Catabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Methylation Response To Testosterone Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	Proteolysis Folic Acid-containing Compound Metabolic Process
Pathways		Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs		Adenine (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol Formycin 5\'-Deoxy-5\'-Methylthioadenosine 5\'-Deoxy-5\'-(Methylthio)-Tubercidin	Capromab L-Glutamic Acid (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid
Diseases
GWAS		Coronary heart disease ( 21606135) Cutaneous nevi ( 19578365) Melanoma ( 21983787)	HDL cholesterol ( 19060911) Height ( 20881960)
Protein-Protein Interactions		6 interactors: CDC25A CENPH FOLH1 LYRM1 MYLIP RELB	2 interactors: MTAP RPS3
Entrez ID		4507	2346
HPRD ID		01134	02961
Ensembl ID		ENSG00000099810	ENSG00000086205
Uniprot IDs		B4DUC8 Q13126	Q04609
PDB IDs		1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE	1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW 3RBU 3SJE 3SJF 3SJG 3SJX
Enriched GO Terms of Interacting Partners?			Positive Regulation Of DNA N-glycosylase Activity Purine Ribonucleoside Salvage Negative Regulation Of DNA Repair L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Cytoplasmic Translation Methionine Biosynthetic Process Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Purine-containing Compound Salvage Polyamine Metabolic Process Response To Testosterone Sulfur Amino Acid Metabolic Process Regulation Of DNA Repair
Tagcloud ?		9p 9p21 abilities accounts aggressiveness alanosine anchorage attributable confers hemizygous homozygous immunoexpression inactivated losses methylthioadenosine myxofibrosarcoma myxofibrosarcomas pathogenically phosphorylase portended preserved recurrently reexpressing reexpression reverted spanning umbilical unfavorable xenografts	adam adam17 basing cav1 cav2 cdc42 coexpressed dusp dusp6 fgfr3 flt4 her3 kdr krt18 krt8 lck macroglobulin mmp9 neoangiogenesis pdgfb psm ptk ptp ptpns1 ptprs top2 top2a vav1 vim
Tagcloud (Difference) ?		9p 9p21 abilities accounts aggressiveness alanosine anchorage attributable confers hemizygous homozygous immunoexpression inactivated losses methylthioadenosine myxofibrosarcoma myxofibrosarcomas pathogenically phosphorylase portended preserved recurrently reexpressing reexpression reverted spanning umbilical unfavorable xenografts	adam adam17 basing cav1 cav2 cdc42 coexpressed dusp dusp6 fgfr3 flt4 her3 kdr krt18 krt8 lck macroglobulin mmp9 neoangiogenesis pdgfb psm ptk ptp ptpns1 ptprs top2 top2a vav1 vim
Tagcloud (Intersection) ?