MTAP

Description		methylthioadenosine phosphorylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process Nucleoside Metabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone
Pathways		Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases
GWAS		Adverse response to drug ( 30420678) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous malignant melanoma ( 32341527) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Mean spheric corpuscular volume ( 32888494) Melanoma ( 28212542 21983787) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480 32341527) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)
Novel Interacting Genes		2 novel interacting genes: PKD2 PLCB2
Interacting Genes		7 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP RELB
Entrez ID		4507
HPRD ID		01134
Ensembl ID		ENSG00000099810
Uniprot IDs		A0A384ME80 B4DUC8 Q13126
PDB IDs		1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?		Intestinal Folate Absorption Tetrahydrofolyl-poly(glutamate) Polymer Binding Ac-Asp-Glu Binding Release Of Sequestered Calcium Ion Into Cytosol Metanephric Cortical Collecting Duct Development Cellular Response To Osmotic Stress Metanephric Cortex Development Metanephric Distal Tubule Development Negative Regulation Of Sequestering Of Calcium Ion G-protein Beta/gamma-subunit Complex Cytoskeletal Protein Binding Response To Osmotic Stress Calcium Ion Transmembrane Import Into Cytosol Polycystin Complex Metanephric Smooth Muscle Tissue Development Renal Artery Morphogenesis Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Metanephric Part Of Ureteric Bud Development Regulation Of Sequestering Of Calcium Ion Migrasome Metanephric Ascending Thin Limb Development Distal Tubule Development Cellular Response To Hydrostatic Pressure HLH Domain Binding Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow NF-kappaB Complex Calcium-induced Calcium Release Activity Basal Cortex Nephric Duct Development Mesonephric Duct Development Sensory Perception Of Bitter Taste Glutamate Biosynthetic Process S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Kinetochore Binding Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Phosphatidylinositol Phospholipase C Activity
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