WRNIP1 and RNF26

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		WRNIP1	RNF26
Description		WRN helicase interacting protein 1	ring finger protein 26
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Synthesis Involved In DNA Repair Immune System Process DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Regulation Of DNA-templated DNA Replication Initiation Innate Immune Response	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)	Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: ABL1 CEBPA ERBB3 FXR1 PIK3R3 PIN1 POLD1 POLD2 POLD4 RNF26 TOLLIP TRIM14 UBC WRN	54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1
Entrez ID		56897	79102
HPRD ID		10494	05842
Ensembl ID		ENSG00000124535	ENSG00000173456
Uniprot IDs		Q96S55	Q9BY78
PDB IDs		3VHS 3VHT
Enriched GO Terms of Interacting Partners?		Delta DNA Polymerase Complex DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Response To Stress DNA-templated DNA Replication DNA Replication Macromolecule Metabolic Process Bubble DNA Binding Cellular Response To Stress Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Signaling Cassette DNA Repair 3'-5' Exonuclease Activity Positive Regulation Of Macromolecule Metabolic Process Four-way Junction DNA Binding DNA Conformation Change Ubiquitin Protein Ligase Binding DNA-directed DNA Polymerase Activity Translesion Synthesis Positive Regulation Of Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Mismatch Repair DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Postreplication Repair Positive Regulation Of Gene Expression DNA Damage Response Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Long-term Synaptic Potentiation Phosphotyrosine Residue Binding Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cis-trans Isomerase Activity Exonuclease Activity Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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