WRNIP1 and POLD1

Number of citations of the paper that reports this interaction (PubMedID 15670210)
0

Data Source:
HPRD (in vitro)

		WRNIP1	POLD1
Description		WRN helicase interacting protein 1	DNA polymerase delta 1, catalytic subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Membrane Perinuclear Region Of Cytoplasm	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Nuclease Activity Exonuclease Activity Protein Binding Zinc Ion Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Enzyme Binding DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Immune System Process DNA Replication DNA-templated DNA Replication DNA Repair DNA Damage Response Regulation Of DNA-templated DNA Replication Initiation Innate Immune Response	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways			Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		14 interacting genes: ABL1 CEBPA ERBB3 FXR1 PIK3R3 PIN1 POLD1 POLD2 POLD4 RNF26 TOLLIP TRIM14 UBC WRN	21 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3
Entrez ID		56897	5424
HPRD ID		10494	08882
Ensembl ID		ENSG00000124535	ENSG00000062822
Uniprot IDs		Q96S55	A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0
PDB IDs		3VHS 3VHT	6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		Delta DNA Polymerase Complex DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Response To Stress DNA-templated DNA Replication DNA Replication Macromolecule Metabolic Process Bubble DNA Binding Cellular Response To Stress Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Signaling Cassette DNA Repair 3'-5' Exonuclease Activity Positive Regulation Of Macromolecule Metabolic Process Four-way Junction DNA Binding DNA Conformation Change Ubiquitin Protein Ligase Binding DNA-directed DNA Polymerase Activity Translesion Synthesis Positive Regulation Of Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Mismatch Repair DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Postreplication Repair Positive Regulation Of Gene Expression DNA Damage Response Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Long-term Synaptic Potentiation Phosphotyrosine Residue Binding Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cis-trans Isomerase Activity Exonuclease Activity Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process	DNA Replication DNA Repair DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA-templated DNA Replication DNA Damage Response DNA Strand Elongation Involved In DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Delta DNA Polymerase Complex DNA Strand Elongation Telomere Maintenance Telomere Organization Mitotic Cell Cycle Phase Transition Cyclin D3-CDK4 Complex Cellular Response To Stress Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome, Telomeric Region DNA-directed DNA Polymerase Activity G1/S Transition Of Mitotic Cell Cycle Translesion Synthesis Cell Cycle G1/S Phase Transition Cyclin E1-CDK2 Complex DNA Synthesis Involved In UV-damage Excision Repair Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Postreplication Repair Regulation Of DNA Replication Nucleoplasm Nucleobase-containing Compound Metabolic Process MutLalpha Complex Binding Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process
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