STK38 and HERC5

Number of citations of the paper that reports this interaction (PMID 16884686)
17

Data Source:
BioGRID (pull down)

		STK38	HERC5
Gene Name		serine/threonine kinase 38	HECT and RLD domain containing E3 ubiquitin protein ligase 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm MLL5-L Complex	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity ISG15 Transferase Activity Poly(A) RNA Binding
	Biological Process	Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS			Pulmonary function decline ( 22424883)
Protein-Protein Interactions		8 interactors: CALM1 CTDP1 HERC5 MOB2 S100B TRIM25 YWHAB YWHAZ	10 interactors: CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 NME2 PITX2 STK38 UBE2D1
Entrez ID		11329	51191
HPRD ID		09511	10502
Ensembl ID		ENSG00000112079	ENSG00000138646
Uniprot IDs		Q15208	B4DXV3 E9PBL0 Q9UII4
PDB IDs		1PSB
Enriched GO Terms of Interacting Partners?		Immune Response Defense Response Innate Immune Response Immune System Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Hormone Positive Regulation Of Mitochondrion Organization Response To Stress Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport Response To Steroid Hormone Regulation Of Mitochondrion Organization Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Type I Interferon Production Response To Organic Substance Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Dephosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Viral Process Response To Glucocorticoid Defense Response To Virus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation Golgi Reassembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Corticosteroid Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Signaling Regulation Of Protein Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intrinsic Apoptotic Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Kinase Activity Response To External Stimulus Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Regulation Of Protein Kinase Activity Negative Regulation Of Gene Expression Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Response To Lipid Cell Division Mitotic Cell Cycle Checkpoint Cell Cycle Process Regulation Of Protein Phosphorylation Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Organ Regeneration Cellular Protein Modification Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Mitotic DNA Integrity Checkpoint Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Response To Organic Cyclic Compound Response To UV Response To Hormone
Tagcloud ?		asymmetric axon axons cascade depend dynein establishment evolutionarily invertebrates kinases mechanistically morphogenesis ndr ndr1 ndr2 par3 pard3 perform phosphorylating polarity polarization polarized polarizing rassf5 reinforcing ser383 specification supernumerary	accumulation alternative attractive deletion drugs enhancing inactivation involving isg15 isgylation multistep native oncogene oncogenes p53 promoting propose regulate src stability suppressing suppressor suppressors transformation transformed tumorigenesis turn tyr126 tyr220
Tagcloud (Difference) ?		asymmetric axon axons cascade depend dynein establishment evolutionarily invertebrates kinases mechanistically morphogenesis ndr ndr1 ndr2 par3 pard3 perform phosphorylating polarity polarization polarized polarizing rassf5 reinforcing ser383 specification supernumerary	accumulation alternative attractive deletion drugs enhancing inactivation involving isg15 isgylation multistep native oncogene oncogenes p53 promoting propose regulate src stability suppressing suppressor suppressors transformation transformed tumorigenesis turn tyr126 tyr220
Tagcloud (Intersection) ?