AMER1

Gene Name		APC membrane recruitment protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Beta-catenin Binding
	Biological Process	Wnt Signaling Pathway Bone Development Adipose Tissue Development Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Differentiation Involved In Kidney Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: AXIN1 BTRC CTNNB1 FBXW11 KEAP1
Entrez ID		139285
HPRD ID		06565
Ensembl ID		ENSG00000184675
Uniprot IDs		Q5JTC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Polyubiquitination Embryonic Skeletal Joint Morphogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Embryonic Skeletal Joint Development Positive Regulation Of Circadian Rhythm Dorsal/ventral Axis Specification Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity In Utero Embryonic Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Intracellular Signal Transduction Canonical Wnt Signaling Pathway
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