AMER1

Description		APC membrane recruitment protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Beta-catenin Binding Lipid Binding Beta-catenin Destruction Complex Binding
	Biological Process	Kidney Development Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Bone Development Adipose Tissue Development Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Differentiation Involved In Kidney Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases		Osteopathia striata with cranial sclerosis
GWAS
Interacting Genes		6 interacting genes: AXIN1 BTRC CTNNB1 KEAP1 SRPK2 UBC
Entrez ID		139285
HPRD ID		06565
Ensembl ID		ENSG00000184675
Uniprot IDs		Q5JTC6
PDB IDs		4YJE 4YJL 4YK6
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Catabolic Process Beta-catenin Destruction Complex Wnt Signalosome Proteolysis Proteasomal Protein Catabolic Process Dorsal/ventral Axis Specification I-SMAD Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Disordered Domain Specific Binding Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process In Utero Embryonic Development Regulation Of Canonical Wnt Signaling Pathway Chordate Embryonic Development Positive Regulation Of Protein Metabolic Process Wnt Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Catabolic Process Ubiquitin Protein Ligase Binding SMAD Binding Regulation Of Wnt Signaling Pathway Formation Of Primary Germ Layer Regulation Of Protein Catabolic Process Regulation Of Proteolysis Dorsal/ventral Pattern Formation Lateral Plasma Membrane Positive Regulation Of Neuron Apoptotic Process Axis Specification Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Cell Periphery Canonical Wnt Signaling Pathway Macromolecule Metabolic Process
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