FAM131C and DNAJA3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		FAM131C	DNAJA3
Gene Name		family with sequence similarity 131, member C	DnaJ (Hsp40) homolog, subfamily A, member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Actin Filament IkappaB Kinase Complex Extrinsic Component Of Plasma Membrane Cell Junction Neuromuscular Junction I-kappaB/NF-kappaB Complex Mitochondrial Nucleoid Intracellular Membrane-bounded Organelle Postsynaptic Membrane
	Molecular Function		Small GTPase Regulator Activity Interferon-gamma Receptor Binding Protein Binding ATP Binding Transcription Factor Binding Protein Kinase Binding Hsp70 Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding NF-kappaB Binding Unfolded Protein Binding Chaperone Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrial DNA Replication Protein Folding Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Mitochondrion Organization Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Cell Aging Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity T Cell Differentiation In Thymus Response To Interferon-gamma Protein Refolding Positive Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Catalytic Activity Protein Stabilization Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 19734545)
Protein-Protein Interactions		10 interactors: APP DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1	38 interactors: ALS2CR11 ATXN1 BRCA1 CARM1 COIL FAM131C FAM214B FOSL2 FRMD6 GCC1 GFI1B GRB2 HSPA1A HSPA8 HSPA9 IFNGR2 INPP5J JAK2 KDM1A KRAS MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 RAD51 RASA1 RELA RNF34 SMAD9 STK16 TCF19 USP7 VHL ZBTB22
Entrez ID		348487	9093
HPRD ID		08779	09758
Ensembl ID		ENSG00000185519	ENSG00000103423
Uniprot IDs		Q96AQ9	B3KM81 E7ES32 Q53G26 Q59E88 Q96EY1
PDB IDs			2CTT 2DN9
Enriched GO Terms of Interacting Partners?		Neuron Recognition Neuromuscular Junction Development Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Metaphase Plate Congression Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Developmental Cell Growth Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Recognition Collateral Sprouting In Absence Of Injury Developmental Growth Involved In Morphogenesis Positive Regulation Of Peptidase Activity Cell Growth Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Proteolysis Synapse Organization Regulation Of Phosphorus Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Axon Choice Point Recognition Activation-induced Cell Death Of T Cells Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Neuron Remodeling Blastocyst Hatching Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Mitochondrial DNA Replication Negative Regulation Of Peptidase Activity Developmental Growth	Response To Abiotic Stimulus Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Response To Organic Substance Response To Organonitrogen Compound Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Cellular Response To Stress Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Viral Process Positive Regulation Of NF-kappaB Transcription Factor Activity Transcription, DNA-templated Regulation Of Signaling RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Histone H3-R2 Methylation Response To Organic Cyclic Compound Response To Radiation Regulation Of Histone H3-K4 Methylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cellular Response To Organonitrogen Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Stimulus Response To Temperature Stimulus
Tagcloud ?			acted adenocarcinoma allylamino causing cochaperone colony concluded conversely counteracting counterparts demethoxy differently egfr enhancing geldanamycin hsp70 hsp90 interacted inversely isoforms oncogenic orthotropic proteasomal restored subcutaneous tid1 ubiquitinylation xenograft
Tagcloud (Difference) ?			acted adenocarcinoma allylamino causing cochaperone colony concluded conversely counteracting counterparts demethoxy differently egfr enhancing geldanamycin hsp70 hsp90 interacted inversely isoforms oncogenic orthotropic proteasomal restored subcutaneous tid1 ubiquitinylation xenograft
Tagcloud (Intersection) ?